Results 71 to 80 of about 2,511,519 (330)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

MECHANICAL REGENERATION OF SAND WASTE

Литьë и металлургия, 2005
The experimental activation of the sand regenerator of the firm SINTO is carried out at ОАО “MZOO". It is shown that sand grains are cleared from films of binding agents, that allows to use the treated sand for preparation of agglutinant and core sands.
D. I. Gnir, E. V. Govinchik
doaj  

Numerical Study on Peak Shaving Performance of Combined Heat and Power Unit Assisted by Heating Storage in Long-Distance Pipelines Scheduled by Particle Swarm Optimization Method

Energies
Thermal energy storage in long-distance heating supply pipelines can improve the peak shaving and frequency regulation capabilities of combined heat and power (CHP) units participating in the power grid.
Haoran Ju, Yongxue Wang, Yiwu Feng, Lijun Zheng   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Control of gas-dynamic conditions of cupola process

Литьë и металлургия, 2003
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I. A. Potapnev, I. I. Bolmatenkova
doaj  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Method of carbon monoxide elimination during cupola furnace process

Литьë и металлургия, 2001
The work is of interest to the enterprises operating open type cupola. The suggested method of afterburning ensures reduction of CO level below maximum permissible concentration.
S. F. Lukashevich, I. A. Potapnev
doaj  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The nomographic charts for calculation and adjustment of mixture at melting of cast iron in cupolas

Литьë и металлургия, 2003
There are offered nomographic charts for calculation and adjustment of mixture at casting of gray and white cast iron in cupola furnaces. The nomographic charts allow to reduce calculations of mixtures, to facilitate the receiving of the intended ...
L. Z. Pisarenko, F. S. Lukashevich, D. V. Kuis   +2 more
doaj  

An estimation of exergy consumption paterns of energy‐intensive building service systems

Journal of Civil Engineering and Management, 2006
This paper represents the estimation of life cycle exergy consumption for building service systems (BSS). The investigation explores public building engineering systems, which are the most energy‐intensive.
Darius BiekÅ¡a, Vytautas Martinaitis, Aloyzas Algimantas Å akmanas   +2 more
doaj   +1 more source