Results 21 to 30 of about 1,223,101 (358)
The light chain but not the heavy chain of botulinum A toxin inhibits exocytosis from permeabilized adrenal chromaffin cells [PDF]
, 1989 The heavy and light chains of botulinum A toxin were separated by anion exchange chromatography. Their intracellular actions were studied using bovine adrenal chromaffin cells permeabilized with streptolysin O.
Ahnert-Hilger, G. +4 more
core +1 more source
Novel exons and splice variants in the human antibody heavy chain identified by single cell and single molecule sequencing. [PDF]
PLoS ONE, 2015 Antibody heavy chains contain a variable and a constant region. The constant region of the antibody heavy chain is encoded by multiple groups of exons which define the isotype and therefore many functional characteristics of the antibody.
Christopher Vollmers +3 more
doaj +1 more source
Mediterranean Journal of Hematology and Infectious Diseases, 2023 Heavy chain diseases are rare B-cell neoplasms consisting of the production of a monoclonal immunoglobulin composed of the only heavy chain without corresponding light chains.
Maria Laura Bisegna +5 more
doaj +1 more source
Klinicka Onkologie, 2020 Gamma-heavy chain disease is a rare disease, described so far in approximately 150 cases. The aim of this work was laboratory dia-gnostics of immunoglobulin heavy chain disease.A 60-year-old patient was referred to the University Hospital in Ostrava for suspected marginal zone lymphoma from gastric bio-psy.
Tomas Jelinek +3 more
openaire +2 more sources
Flatness of heavy chain systems [PDF]
Proceedings of the 41st IEEE Conference on Decision and Control, 2002., 2001 This paper gives an overview of the results of Petit and Rouchon (2001). Furthermore it contains some previously unpublished material concerning the homogeneous chain carrying a load. In the above paper the flatness of heavy chain systems, i.e. trolleys carrying a fixed length heavy chain that may carry a load, is addressed in the partial derivatives ...
Pierre Rouchon, Nicolas Petit
openaire +2 more sources
A role for Tctex-1 (DYNLT1) in controlling primary cilium length [PDF]
, 2011 The microtubule motor complex cytoplasmic dynein is known to be involved in multiple processes including endomembrane organization and trafficking, mitosis, and microtubule organization.
MacCarthy-Morrogh, LJ +3 more
core +1 more source
Heavy-Chain Deposition Disease [PDF]
New England Journal of Medicine, 1993 Comment inOminous consequences of immunoglobulin deposition. [N Engl J Med. 1993]
Aucouturier, Pierre +7 more
openaire +2 more sources
IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design [PDF]
, 2017 Rodent monoclonal antibodies with specificity towards important biological targets are developed for therapeutic use by a process of humanisation. This process involves the creation of molecules, which retain the specificity of the rodent antibody but ...
Angal +34 more
core +1 more source
A simple way to increase recovery of the expressed VH and VL genes in single-sorted human B cells
BioTechniques, 2019 Cloning VH and VL genes from individual antigen-specific B cells is an attractive approach for producing monoclonal antibodies of the desired specificity.
Sergey V Guselnikov +4 more
doaj +1 more source
mAbs, 2021 Human/humanized IgG4 antibodies have reduced effector function relative to IgG1 antibodies, which is desirable for certain therapeutic purposes. However, the developability and biophysical properties for IgG4 antibodies are not well understood. This work
Pin-Kuang Lai +5 more
doaj +1 more source