Results 131 to 140 of about 584,932 (288)

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

On the practical utility of a continuum traffic flow model on curvy highways in adverse weather conditions

Transportation Research Interdisciplinary Perspectives
The macroscopic continuum traffic flow models are being investigated to predict and ameliorate traffic more efficiently. These models are beneficial implementation tools to comprehend and complement the shortfalls in traffic evolution.
Waheed Imran, Zawar H. Khan, Daud Khan, Usman Ghani, Tahseen Bashir   +4 more
doaj   +1 more source

Quantum Dots for Biomedical Biosensing, NIR‐II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers

Advanced Science, EarlyView.
This review outlines bottom‐up and biomimetic fabrication strategies of quantum dots, and highlights their emerging applications in biosensing, multimodal bioimaging, and intelligent cancer theranostics. It further discusses key translational barriers and future perspectives for advancing QD‐based nanomedicine toward clinical implementation.
Jie Ju, Zhifang Liu, Xinran Gao, Wen Sun, Wei Fu, Yanfei Wang   +5 more
wiley   +1 more source

Risk Analysis of Atmospheric Heavy Metals in Industrial, Traffic, and Residential Areas of Ahvaz City [PDF]

تحقیقات سلامت در جامعه
Introduction and purpose: Nowadays, the use of biomonitoring to determine air quality is continuously increasing. Heavy metals are of interest among air pollutants due to their detrimental effects on health.
Gholamreza Goudarzi, Zeynab Baboli, Ruhollah Khodadadi*, Mohammad Sohrabi, Yaser Tahmasebi Birgani, Ali Akbar Babaei, Abdolkazem Nisi, Maryan Dastoorpoor, Stefano Loppi   +8 more
doaj  

From continuous to interruptible distillation: Flexible electric heating column architecture with fast start‐up

AIChE Journal, EarlyView.
Abstract Electrification of distillation offers a promising route to reducing scope‐1 emissions from one of the chemical industry's most energy‐intensive unit operations. However, conventional adiabatic columns are dynamically inflexible: Long, energy‐intensive start‐ups make shutdown and restart impractical under variable electricity prices and ...
Samuel Mercer, Michael Baldea
wiley   +1 more source

Diffusion Limits for the Queue Length of Jobs in Multiserver Open Queueing Networks

Operations Research and Decisions, 2017
A mathematical model of a multiserver open queueing network in heavy traffic is developed. This model is that of a multiserver computer system network in heavy traffic. A limit theorem for the length of the queue has been presented. (original abstract)
Edvinas Greičius, Saulius Minkevičius
doaj  

Traffic Simulation-Based Sensitivity Analysis of Long Underground Expressways

Applied Sciences
Long underground expressways have emerged as an alternative to surface highways in densely urbanized areas; however, their enclosed geometry, extended length, and steep longitudinal gradients introduce traffic-flow dynamics distinct from those of surface
Choongheon Yang, Chunjoo Yoon
doaj   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

Multi-component matching queues in heavy traffic

Queueing Systems
We consider multi-component matching systems in heavy traffic consisting of $K\geq 2$ distinct perishable components which arrive randomly over time at high speed at the assemble-to-order station, and they wait in their respective queues according to their categories until matched or their ``patience" runs out.
openaire   +3 more sources

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source