Results 131 to 140 of about 65,792 (310)

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science, EarlyView.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
wiley   +1 more source

A LIFO queue in heavy traffic

The Annals of Applied Probability, 2001
The author analyzes the heavy-traffic behaviour of an M/G/1 last-in-first-out preemptive resume queue using measure-valued processes developed by \textit{J.-F. Le Gall} and \textit{Y. Le Jan} [Ann. Probab. 26, No.~4, 1407-1432 (1998; Zbl 0945.60090)]. This approach captures all the relevant information about evolution of the queue.
openaire   +3 more sources

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

Construction Material for Tribo-Fatigue Systems: Fatigue Resistance and Structure

Механика машин, механизмов и материалов, 2018
A brief overview of the practical use of the new construction material of MONICA is given. An experimental study was performed for the first time on the analysis of the influence of the microstructural state on fatigue resistance.
Leonid A. Sosnovskiy, Alexander A. Novikov, Sergey S. Sherbakov, Victor V. Commissarov, Sergey A. Tyurin, Pavel S. Drobyshevskiy   +5 more
doaj  

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

An Approach for Characterising Heavy-Tailed Internet Traffic Based on EDF Statistics

In this research, statistical analyses of Web traffic were carried out based on the Empirical Distribution Function (EDF) test. Several probability distributions, such as Pareto (simple), extreme value, Weibull (three parameters), exponential, logistic ...
Mohammed Rezaul, Karim, Grout, Vic
core   +1 more source

Assessing health risk reduction from road traffic noise: The impact of vehicle composition and traffic speed in the transition to electric vehicles – A prediction in Sapporo City, Japan

Hygiene and Environmental Health Advances
Environmental noise poses a risk to public health. Recent societal shifts aimed at creating a low-carbon society are expected to change the acoustic landscape, such as the transition from internal combustion engine vehicles (ICEVs) to electric vehicles ...
Farah Elida Selamat, Junta Tagusari
doaj   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

Management of traffic-related effects of heavy vehicles on urban freight corridors

, 2006
Increasing demand for road freight has lead to a greater adoption of more-productive multi-combination vehicles on roads that are generally also used as major arterial corridors for non-freight traffic. This paper reports on a study into the effects that
Ramsay, Euan D., Bunker, Jonathan M., Bruzsa, Les   +2 more
core