Results 31 to 40 of about 47,318 (263)

How the Volume of Traffic Affected Air Quality During the Extreme Event of COVID-19 Lockdown in a Small City

Promet (Zagreb), 2022
The extreme traffic measures during the COVID-19 lockdown provided a unique opportunity to gain better insight into the relationship between traffic characteristics and NO2 concentrations in Maribor, a small Slovenian city.
Branka Trček, Rok Kamnik
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

STUDY OF THE INFLUENCE OF THE PASSAGE OF HEAVY TRAINS ON THE THROUGHPUT AND CARRYING CAPACITY OF RAILWAY SECTIONS WITH ELECTRIC TRAIN TRACTION

International Journal of Advanced Studies, 2022
The criterion for the effectiveness of the organization of heavy traffic on the sections of the Russian railway network is the presence of large correspondences of bulk goods presented by the consignor for transportation.
Valentina V. Shirokova, Natalya A. Kuzmina, Tatyana A. Odudenko, Galina V. Sankova   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

On Priority Queues in Heavy Traffic

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1970
Summary For single-server, first-come-first-served queues, specified completely by the sequences of interarrival times and service times, if these sequences are stationary and if (in some sense) there is not too much dependence within or between them, it has been shown by Kingman (1962) that the waiting-time distribution is, in heavy ...
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Probabilistic Assessment of Transit Heavy-Vehicle Impacts on CO₂e Emissions and External Pollution Costs in Urban Transport Corridors

Applied Sciences
Heavy-duty transit vehicles (N1–N3) (heavy vehicles) can generate disproportionate environmental and economic impacts in urban transport corridors despite representing a relatively small share of total traffic volume.
Artūras Petraška, Kristina Čižiūnienė, Jūratė Liebuvienė, Vida Jokubynienė, Edgar Sokolovskij   +4 more
doaj   +1 more source

Passenger Car Equivalents for Heavy Vehicles at Roundabouts. a Synthesis Review

Frontiers in Built Environment, 2019
Passenger Car Equivalents (PCEs in the following) are used to transform a mixed fleet of vehicles into a fleet of equivalent passenger cars and to analyze capacity and level-of-service of roads and intersections.
Orazio Giuffrè, Anna Granà, Tullio Giuffrè, Maria Luisa Tumminello, Francesco Acuto   +4 more
doaj   +1 more source

Heavy Traffic Analysis of Polling Systems in Tandem [PDF]

Operations Research, 1999
We analyze the performance of a tandem queueing network populated by two customer types. The interarrival times of each type and the service times of each type at each station are independent random variables with general distributions, but the load on each station is assumed to be identical.
Reiman, Martin I., Wein, Lawrence M.
openaire   +2 more sources