Results 211 to 220 of about 201,870 (394)

Identification of novel genes regulating the development of the palate

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley   +1 more source

Molecular anatomy of emerging Xenopus left–right organizer at successive developmental stages

open access: yesDevelopmental Dynamics, Volume 254, Issue 8, Page 950-964, August 2025.
Abstract Background Vertebrate left–right symmetry breaking is preceded by formation of left–right organizer. In Amphibian, this structure is formed by gastrocoel roof plate, which emerges from superficial suprablastoporal cells. GRP is subdivided into medial area, which generates leftward flow by rotating monocilia and lateral Nodal1 expressing areas,
Natalia Petri   +3 more
wiley   +1 more source

Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway [PDF]

open access: hybrid, 1997
John C. Sisson   +3 more
openalex   +1 more source

BMP4 regulates asymmetric Pkd2 distribution in mouse nodal immotile cilia and ciliary mechanosensing required for left–right determination

open access: yesDevelopmental Dynamics, Volume 254, Issue 8, Page 965-978, August 2025.
Abstract Background Mouse nodal immotile cilia mechanically sense the bending direction for left–right (L–R) determination and activate the left‐side‐specific signaling cascade, leading to increased Nodal activity. Asymmetric distribution of Pkd2, a crucial channel for L–R determination, on immotile cilia has been reported recently. However, the causal
Takanobu A. Katoh   +5 more
wiley   +1 more source

Saikosaponin b1 Attenuates Liver Fibrosis by Blocking STAT3/Gli1 Interaction and Inducing Gli1 Degradation

open access: yesExploration, EarlyView.
Saikosaponin b1 attenuates liver fibrosis by competitively disrupting the interaction between signal transducer and activator of transcription 3 (STAT3) and glioma‐associated oncogene‐1 (Gli1) in the activated hepatic stellate cells (HSCs). The blocked interaction of STAT3 and Gli1 promotes the degradation of Gli1, inhibits Gli1 transcriptional ...
Meiyu Shao   +15 more
wiley   +1 more source

Glia Preserve Their Own Functions While Compensating for Neighboring Glial Cell Dysfunction

open access: yesGlia, EarlyView.
When cortex glia lose their interactions with neuronal cell bodies, all neighboring glia infiltrate the region to clear extra neuronal corpses. Even while compensating for nearby glial dysfunction, glia maintain their own phagocytic functions. ABSTRACT Glial cells are essential for nervous system development, homeostasis, and disease response, engaging
Allison N. Beachum   +13 more
wiley   +1 more source

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