Results 321 to 330 of about 201,870 (394)

Navigating the Molecular Signaling: Deciphering Cancer Stem Cell Self-Renewal Pathways. [PDF]

Int J Mol Cell Med
Hoseinian SN, Saeedi M, Saravani ME, Zenoozi S, Mehranfar F, Pouyan A.   +5 more
europepmc   +1 more source

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

British Journal of Pharmacology, EarlyView.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota, Theodora Calogeropoulou, Konstantina Chanoumidou, Ioannis Charalampopoulos, Achille Gravanis   +4 more
wiley   +1 more source

Hedgehog Signaling Functions in Spermatogenesis and Keeping Hemolymph-Testis Barrier Stability in <i>Eriocheir sinensis</i>. [PDF]

Int J Mol Sci
Yu JJ, Qi HY, Zhao Z, Yang Y, Zhang SY, Tan FQ, Yang WX.   +6 more
europepmc   +1 more source

Beyond synapses: cytoplasmic connections in brain function and evolution

Biological Reviews, EarlyView.
ABSTRACT Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non‐synaptic interactions among neural cells.
Malalaniaina Rakotobe, Chiara Zurzolo
wiley   +1 more source

Exploring resveratrol's inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models. [PDF]

Med Oncol
Saiful Hakim AR, Chee CF, Wong TW, Abu Kasim NH, Nasruddin NS, Yazid F.   +5 more
europepmc   +1 more source

How Do Cancer Cells Create Cancer‐Associated Fibroblast Subtypes? Impacts of Extracellular Vesicles on Stromal Diversity

Cancer Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) are the major component of the tumor stroma. This review will highlight the CAF subtypes within the tumor microenvironment and their role in tumor progression. CAF subtype induction by extracellular vesicles (EVs) and their significance, which we reported previously, are also discussed.
Yutaka Naito
wiley   +1 more source

Chinese medicine monomers for hepatocellular carcinoma: New ideas related to autophagy. [PDF]

World J Gastroenterol
Zheng SH, Xue TY, Wang QY, Ye YA, Zhang P.   +4 more
europepmc   +1 more source

PRRX2 Regulates GLI2 to Promote Proliferation, Invasion, and Metastasis by Inhibiting Senescence via Hedgehog Signaling

Cancer Science, EarlyView.
PRRX2 is highly expressed in pancreatic cancer and correlates with patient prognosis. PRRX2 promotes pancreatic cancer cell proliferation, invasion, and metastasis, and inhibits pancreatic cancer cell senescence. PRRX2 transcriptionally regulates GLI2 and activates the Hedgehog pathway.
Wei Huang, Feiqiang xu, Jichuan xu, Gang Quan, Shihang zhang, Mengmeng guo, Feng xiao, Jianxin jiang   +7 more
wiley   +1 more source

POU5F1 bridges Hedgehog signaling and epithelial remodeling in COPD. [PDF]

Front Cell Dev Biol
Petit LMG, Belgacemi R, Mulette P, Brisebarre A, Saber Cherif L, Devilliers MA, Hatoum S, Ancel J, Delepine G, Durlach A, Polette M, Deslée G, Perotin JM, Dormoy V.   +13 more
europepmc   +1 more source

PIK3C2A‐Related Clinical Phenotype and Cellular Charaterization Linked to Functional SHH Primary Cilia Defect

Clinical Genetics, EarlyView.
Trio exome sequencing allowed the identification of two novel compound heterozygous variants in PIK3C2A, defining the fifth family presenting a PIK3C2A‐related syndrome characterized by pulverulent cataracts and deafness. Functional testing revealed impaired PI metabolism and primary dysfunction phenotype.
Adella Karam, Clarisse Delvallée, Bénédicte Gérard, Elodie Javey, Pascal Kessler, Valérie Pelletier, Jean‐Baptiste Lamouche, Nicolas Le May, Jean Muller, Hélène Dollfus   +9 more
wiley   +1 more source