Results 91 to 100 of about 2,340,031 (328)

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

Hedgehog Signaling: An Achilles’ Heel in Cancer

Translational Oncology, 2019
Hedgehog signaling pathway originally identified in the fruit fly Drosophila is an evolutionarily conserved signaling mechanism with crucial roles in embryogenesis, growth and patterning. It exerts its biological effect through a signaling mechanism that
Madiha Niyaz, Mosin S Khan, Syed Mudassar   +2 more
doaj  

The Proteasome and Cul3-Dependent Protein Ubiquitination Is Required for Gli Protein-Mediated Activation of Gene Expression in the Hedgehog Pathway

Cells
Many cellular processes are regulated by proteasome-mediated protein degradation, including regulation of signaling pathways and gene expression. Among the pathways regulated by the ubiquitin–proteasome system is the Hedgehog pathway and its downstream ...
Tomasz Uśpieński, Paweł Niewiadomski
doaj   +1 more source

Control of Hedgehog Signalling by the Cilia-Regulated Proteasome

Journal of Developmental Biology, 2016
The Hedgehog signalling pathway is evolutionarily highly conserved and essential for embryonic development of invertebrates and vertebrates. Consequently, impaired Hedgehog signalling results in very severe human diseases, ranging from holoprosencephaly ...
Christoph Gerhardt, Antonia Wiegering, Tristan Leu, Ulrich Rüther   +3 more
doaj   +1 more source

Targeting the Hedgehog Pathway in Pediatric Medulloblastoma [PDF]

Cancers, 2015
Medulloblastoma (MB), a primitive neuroectomal tumor of the cerebellum, is the most common malignant pediatric brain tumor. The cause of MB is largely unknown, but aberrant activation of Hedgehog (Hh) pathway is responsible for ~30% of MB. Despite aggressive treatment with surgical resection, radiation and chemotherapy, 70%–80% of pediatric ...
Huang, Sherri Y., Yang, Jer-Yen
openaire   +2 more sources

CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

Advanced Science, EarlyView.
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan, Huzi Zhao, Lili Gao, Yucheng Dong, Pei Zhang, Pengfei Yu, Yunfei Ji, Zhe‐Sheng Chen, Xinmiao Liang, Yang Chen   +9 more
wiley   +1 more source

Elucidating Hedgehog pathway's role in HNSCC progression: insights from a 6-gene signature

Scientific Reports
With the emergence of targeted inhibition strategies for Hedgehog signaling in cancer, multiple Hedgehog signaling pathway-related biomarkers have become the focus of research.
Yang Yang, Chenxi Yang, Qiying Yang, Shun Lu, Bisheng Liu, Dongyun Li, Dongliang Li, Peng Zhang, Peng Xu, Jinyi Lang, Jie Zhou   +10 more
doaj   +1 more source

Research progress on the role of Hedgehog signaling pathway in renal interstitial fibrosis

Linchuang shenzangbing zazhi, 2020
Renal interstitial fibrosis is the common progressive pathway for many chronic kidney diseases.The activation of Hedgehog signaling pathway seems to play an important role in progression of chronic kidney diseases as much as in embryonic renal ...
ZHOU Lan-qi, ZHOU Jian-hua
doaj  

Identification of a potent antagonist of smoothened in hedgehog signaling

Cell & Bioscience, 2021
Background Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics.
Junwan Fan, Haowen Li, Lun Kuang, Zichen Zhao, Wenyan He, Chen Liu, Yongjun Wang, Steven Y. Cheng, Wei Chen   +8 more
doaj   +1 more source

Complete Conjugacy Invariants of Nonlinearizable Holomorphic Dynamics [PDF]

arXiv, 2009
Perez-Marco proved the existence of non-trivial totally invariant connected compacts called hedgehogs near the fixed point of a nonlinearizable germ of holomorphic diffeomorphism. We show that if two nonlinearisable holomorphic germs with a common indifferent fixed point have a common hedgehog then they must commute.
arxiv