Results 111 to 120 of about 1,302,226 (294)

“Nature's Polymer Reimagined: Conventional and Green Routes to Pectin, Its Bioactive Promise and Industrial Applications”

Food Chemistry International, EarlyView.
Pectin, a versatile natural polymer, is extracted through conventional and emerging green extraction methods, offering multifunctional bioactive properties useful in food, pharmaceutical, and environmental applications. ABSTRACT Pectin, a molecular tapestry woven from diverse polysaccharides, holds a pivotal role across food, pharmaceutical, and ...
Afra Anika Rafique, Aunwesha Sahani, Md Morsaline Billah, Kazi Mohammed Didarul Islam   +3 more
wiley   +1 more source

Evaluation of the Hedgehog pathway activation patterns.

, 2019
A: Hierarchical clustering of continuous IHC measurements for the assessment of the Hedgehog pathway activity patterns, N = 183. B, C: Kaplan-Meier curves according to cluster membership. B: 5-year DFS; C: 5-year OS.
Kyriakos Chatzopoulos (3184884), George Fountzilas (8221), Sotirios Lakis (3744785), Vassiliki Kotoula (161014), Georgia Raptou (436151), Nikolaos Dombros (6057605), Alexios Papanikolaou (6057602), Dimitrios Tsolakidis (6057599), Eleni Vrettou (53830), Mattheos Bobos (53836), Georgia Karayannopoulou (3744897), Genovefa Polychronidou (6057593), Ioannis Kostopoulos (53833), Dimitrios Dionysopoulos (6057596), Sofia Chrisafi (161038), Kyriaki Manousou (429780), Ioannis Efstratiou (439182)   +16 more
core   +1 more source

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

Beilstein Journal of Organic Chemistry, 2012
Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity ...
Chao Che, Song Li, Bo Yang, Shengchang Xin, Zhixiong Yu, Taofeng Shao, Chuanye Tao, Shuo Lin, Zhen Yang   +8 more
doaj   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Hepatocyte‐Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies

iNew Medicine, EarlyView.
This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley   +1 more source

GSK3 Inhibition During Annelid Head Regeneration Results in a Hyper‐Proliferative Blastema and Impaired Differentiation

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
A whole‐body regenerative annelid was treated with a GSK3 inhibitor. While posterior regeneration was mostly normal, GSK3 inhibition prevented differentiation of anterior‐specific structures and instead produced a persistent, oversized, hyper‐proliferative blastema. This suggests that GSK3 promotes anterior identity and halts proliferation during axial
James D. Nowotny, Eduardo E. Zattara, Maria Balarezo, Kevin G. Nyberg, Kenna M. Costello, Alexandra E. Bely   +5 more
wiley   +1 more source

Activated status of Hedgehog pathway in oral squamous cell carcinoma (OSCC): the door is still open

, 2016
The Hedgehog (Hh) signaling pathway is essential for regulation of cell differentiation and organ formation in a concentration-dependent manner during embryonic development. Also, this pathway is important to the maintenance of adult stem cells.
Roa Strauch Juan Carlos Enrique, Riquelme, Ismael   +1 more
core   +1 more source

The acetylation GLI1 affects arsenical-induced renal fibrosis by mediating the Hedgehog signalling pathway

Ecotoxicology and Environmental Safety
Arsenic exposure by drinking water is a key challenge in the field of public health worldwide. Research has found a connection between arsenic exposure and renal fibrosis, yet the mechanisms behind this are still unclear. In this study, rats were exposed
Pinya Liu, Yating Wang, Peiyu Jin, Qing Zhou, Liang Pei, Shuhua Xi   +5 more
doaj   +1 more source

Hepatic Adenomas in Men: Diagnostic Considerations and Management in the Modern Era

Journal of Surgical Oncology, EarlyView.
ABSTRACT Hepatic adenomas (HAs) are rare benign liver tumors traditionally associated with young women, yet contemporary epidemiologic trends reveal increasing recognition among men. Historically, universal resection in males has been recommended because of a nearly tenfold increased risk of malignant transformation as reported by Farges et al.
Teresa Belledent, Julie Nwosu, Kiers Brevik, Raegen M. Abbey, Timothy Pawlik, Dae Sun Hwang, Terry L. Hayes, Ikenna Nwosu, Mohammed O. Suraju, Hassan Aziz   +9 more
wiley   +1 more source

Acyl guanidine derivatives modulating the hedgehog protein signaling pathway

, 2011
The present invention relates to acyl guanidine derivatives modulating the hedgehog protein signaling pathway to be used as drugs, in particular for treating diseases involving a tissue dysfunction associated with a deregulation of the hedgehog protein ...
Traiffort E, Roudaut H, Schoenfelder A, Ruat M, MANETTI, FABRIZIO, Mann A, TADDEI, MAURIZIO, Fraure H, Solinas A.   +8 more
core   +1 more source