Results 121 to 130 of about 1,302,226 (294)

Thermal Injury Producing Melanoma‐Like Features on Reflectance Confocal Microscopy

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objectives Reflectance confocal microscopy (RCM) improves diagnostic specificity for equivocal pigmented lesions; however, certain conditions may mimic melanoma and limit its accuracy. We aimed to characterize RCM features of thermally injured lesions that mimic melanoma.
Noa Kremer, Isabella N. Dana, Miguel Cordova, Aditi Sahu, Cristian Navarrete‐Dechent, Ashfaq A. Marghoob   +5 more
wiley   +1 more source

Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer

, 2005
The Hedgehog-GLI signaling pathway is important in animal development and tumorigenesis. Recent findings indicate that the growth and survival of human prostate cancer cells rely upon sustained signaling from the Hedgehog-GLI pathway. These findings have
Virginie Clement, Ariel Ruiz I Altaba, Sanchez, Pilar, Ruiz Altaba, Ariel, Pilar Sanchez, Clement, Virginie, Clement V, Sanchez P, Ruiz i Altaba A   +8 more
core   +1 more source

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

Protein Glutamylation: From Cytoskeleton to Signaling

Med Research, EarlyView.
Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen, Yi Yuan, Qingquan Yu, Xinyue Wang, Hui Wang   +4 more
wiley   +1 more source

Related Articles from Targeting the Hedgehog Pathway in Cancer: Can the Spines Be Smoothened?

, 2011
Related Articles from Targeting the Hedgehog Pathway in Cancer: Can the Spines Be ...
Laurie Ailles (3431195), Lillian L. Siu (6710201)   +1 more
core   +1 more source

Acyl guanidine derivatives modulating the hedgehog protein signaling pathway

, 2014
The present invention relates to acyl guanidine derivatives modulating the hedgehog protein signaling pathway to be used as drugs, in particular for treating diseases involving a tissue dysfunction associated with a deregulation of the hedgehog protein ...
Faure H., Roudaut H., MANETTI, FABRIZIO, Ruat M., TADDEI, MAURIZIO, Traiffort E., Schoenfelder A., Mann A., Solinas A.   +8 more
core   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Paradoxical prosteatotic effect of hedgehog signaling pathway inhibition under conditions of steatosis

, 2012
Paradoxical prosteatotic effect of hedgehog signaling pathway inhibition under conditions of ...
Balsano C, Arciello M, Gori M, Barbaro B
core   +1 more source

Investigational agents in metastatic basal cell carcinoma: focus on vismodegib

Journal of Experimental Pharmacology, 2012
Nicolas Batty,1 Ellen Kossoff,2 Grace K Dy11Department of Medicine, Roswell Park Cancer Center, Buffalo, NY, USA; 2Department of Pharmacy, Roswell Park Cancer Center, Buffalo, NY, USAAbstract: Vismodegib (GDC-0449, 2-chloro-N-(4-chloro-3-(pyridin-2-yl ...
Batty N, Kossoff E, Dy GK
doaj  

Mechanisms and impacts of future plant invasions: research agendas and management needs under disruptive social‐ecological change scenarios

Oikos, EarlyView.
No‐analogue futures are characteristic of the Anthropocene, but how global change, and societies' responses, will affect plant invasions remains unclear. Conducting research now to address future needs is crucial for guiding invasion management and policy.
Jennifer L. Bufford, Angela J. Brandt, Rowan Sprague, Christopher E. Buddenhagen, Richard P. Duncan, Nichola Harcourt, Philip E. Hulme, Hao Ran Lai, Kate G. McAlpine, Chris McGrannachan, Fiona J. Thomson, Vincent van Uitregt, Duane A. Peltzer   +12 more
wiley   +1 more source