Results 141 to 150 of about 58,440 (262)

Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma. [PDF]

Sci Rep
Wang HG, Lu MX, Sheng ML, Lou YB, Xiao YC, Guo A, Yu ZH.   +6 more
europepmc   +1 more source

Cortical‐Hypothalamic Assembloids Uncover the Cortical Regulation of Hypothalamic Responses to Fatty Acid

Cell Proliferation, EarlyView.
By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao, Xiaowen Du, Qi Chen, Wenxin Mu, Shuning Lou, Xu Zhang, Min Xu, Jiting Li, Yuxuan Guo, Wanying Zhu, Yan Liu   +10 more
wiley   +1 more source

STK38-mediated feedback loop regulation of the hedgehog pathway governing tumor heterogeneity in renal papillary carcinoma. [PDF]

Cell Death Dis
Du Y, Sui X, Zheng Z, Zhang Z, Liu B, Bai Y, Zhao Y, Wu Q, Wu H, Zhong M, Li L, Sun H, Shao C.   +12 more
europepmc   +1 more source

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

Cell Proliferation, EarlyView.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang, Ao Wang, Xiangyu Li, Peng Huang, Kaixuan Zeng, Lu Sun, Moxuan Li, Yixiang Chen, Jiancheng Wang   +8 more
wiley   +1 more source

Hedgehog pathway, cell cycle, and primary cilium. [PDF]

Cell Death Discov
Zhuang T.
europepmc   +1 more source

Depicting the Immunological Landscape of Basal Cell Carcinoma Subtypes

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Anti‐PD‐1 response has been associated with higher PD‐1 ligand (PD‐L1) expression levels in different cancer types. Cemiplimab, an anti‐PD‐1 antibody, has been shown to induce a response rate of 31% and 22% in patients with locally advanced basal cell carcinoma (BCC) and metastatic BCC respectively, who have progressed or are ...
Isabella Dommann, Gaetana Restivo, Isabel Kolm, Federica Sella, Patrick Turko, Phil F. Cheng, Mitchell Levesque, Corina Dommann‐Scherrer, Reinhard Dummer, Egle Ramelyte   +9 more
wiley   +1 more source

Analyzing Hedgehog pathway-related genes: insights into breast cancer tumor microenvironment and prognostic implications. [PDF]

Front Immunol
Wang Z, Wang H.
europepmc   +1 more source

The Hedgehog Pathway Promotes Monocytes Infiltration Through CCL20-CCR6 Axis in Hepatocellular Carcinoma. [PDF]

J Cell Mol Med
Chu PH, Hsu YF, Chang CY, Leu CM, Chen KH, Chang CF, Tseng PH.   +6 more
europepmc   +1 more source

Hedgehog (Hh) pathway [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Tuning the Hedgehog pathway [PDF]

Nature Reviews Molecular Cell Biology, 2012
openaire   +1 more source