Results 161 to 170 of about 1,302,226 (294)

Protein phosphatase 2A/Hedgehog pathway governs efferocytosis of pulmonary macrophages and participates in nanoplastics-induced mouse lung injury. [PDF]

Cell Biol Toxicol
Zhang J, Zhang Y, Wen L, Li Z, Cai Y, Wan M, Li W, Zhu X, Pang Y, Li D, Chen S, Guo P, Wang Q, Chen W, Chen L.   +14 more
europepmc   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Aberrant Activation of the Hedgehog Pathway in Cutaneous Melanoma: Therapeutic Potential of Pharmacological Inhibitors. [PDF]

Int J Mol Sci
Papaccio F, Kovacs D, Marrapodi R, Caputo S, Migliano E, Melucci E, Scalera S, Cota C, Maugeri-Saccà M, Bellei B.   +9 more
europepmc   +1 more source

A 30‐year‐old woman with progressive lower extremity sensory loss and weakness

Brain Pathology, EarlyView.
Daniel W. Griepp, Chia‐Ming Lee, Jeffrey P. Turnbull, Sean P. Ferris, Prashant S. Kelkar   +4 more
wiley   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

Hedgehog pathway disruption alters urothelial differentiation and continence mechanisms in the female mouse lower urinary tract. [PDF]

Am J Physiol Renal Physiol
Tanaka LF, Tlapa J, Morrison J, Jordan T, Ridlon M, Ambrogi M, Kracke-Bock JA, Resende A, Eyman MS, Blosch CD, Peter J, Lipinski RJ, Farhat W, Keil Stietz KP.   +13 more
europepmc   +1 more source

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

CMKLR1/PKA signaling reinforces sonic hedgehog pathway to promote medulloblastoma pathogenesis. [PDF]

Oncogenesis
Wang S, Jiang T, Wang T, Yang Z, Wang T, Zhang X, Gou X, Jia L, Wang L, Song Y.   +9 more
europepmc   +1 more source

From sagittal to sprawled: Clavicular co‐option and the evolution of forelimb mechanics in talpines

Journal of Anatomy, EarlyView.
Forelimb posture in Eulipotyphla divides into sagittal and sprawled groups with distinct scapular and clavicular orientations. First true rib strength scales with body mass, reflecting vertical ground reaction forces, whereas clavicular strength reflects differences in medially directed forces on the pectoral girdle, especially pronounced in highly ...
Shin‐ichi Fujiwara, Hiroaki Saito
wiley   +1 more source