Results 151 to 160 of about 58,440 (262)

Nell-1 regulates fibrocartilage stem cells and alleviates temporomandibular joint osteoarthritis progression by inhibiting hedgehog pathway. [PDF]

J Orthop Surg Res
Hu S, Wu N, Wang C, Li W, Shi J.
europepmc   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Thymoquinone mediated hedgehog pathway activation and gut microbiota modulation in mouse colitis. [PDF]

Sci Rep
Huang X, Sun T, Xu L, Liu W, Ren Z, Ma Z, Zheng H, Li D, Wang Q, Ke X.   +9 more
europepmc   +1 more source

Hedgehog pathway in sarcoma: from preclinical mechanism to clinical application. [PDF]

J Cancer Res Clin Oncol, 2023
Banaszek N, Kurpiewska D, Kozak K, Rutkowski P, Sobczuk P.   +4 more
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Butylated hydroxytoluene (BHT) induces zebrafish spinal cord defects and scoliosis by inhibiting the hedgehog pathway. [PDF]

Sci Rep
Cheng H, Li Y, Liu F, Zhu S, Chen L, Lu H, Shi X, Huang L.   +7 more
europepmc   +1 more source

The sorting nexin Snx21 promotes flotillin‐mediated endocytosis

The FEBS Journal, EarlyView.
In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs, Enikő Lakatos, Dalma Feil‐Börcsök, Gábor Juhász, Regina Mező, Asha Kiran Maddali, András Blastyák, Aladár Pettkó‐Szandtner, Hajnalka Laczkó‐Dobos, Gábor Juhász   +9 more
wiley   +1 more source

Evaluation of Benzo[cd]indol-2(1H)-ones as Downstream Hedgehog Pathway Inhibitors. [PDF]

ChemistryOpen
Tsakoumagkos IA, Pasquer QTL, Guillod CL, Rossion C, Bagka M, Torche S, Sakata-Kato T, Chen JK, Hoogendoorn S.   +8 more
europepmc   +1 more source

Stable Isotope–Enabled Particle Drift Models Predict Where High‐Resolution Isotope Analyses Can Discriminate Among Larval Trajectories in Atlantic Mackerel

Fisheries Oceanography, EarlyView.
ABSTRACT Marine fish commonly move across distinct habitats throughout their lifetimes, particularly during larval stages, when they are particularly difficult to track. Such transitions are necessary as environmental demands and predation pressures change dramatically with increases in body size.
Yuan Tian Chou, Robert Marsh, Ewan Hunter, Clive N. Trueman   +3 more
wiley   +1 more source