Results 131 to 140 of about 1,302,226 (294)

Molecular Basis for Uracil‐DNA‐Glycosylase to Identify DNA Damage in the Nucleosome

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The DNA base‐excision repair (BER) pathway is initiated by a glycosylase, such as uracil‐DNA‐glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become even more complex when ...
Safwen Ghediri, Ralf Blossey, Fabrizio Cleri   +2 more
wiley   +1 more source

Investigation of FF-MAS oxysterole’s role in follicular development and its relation to hedgehog signal pathway

Scientific Reports
The Hedgehog signaling pathway plays a crucial role in folliculogenesis; however, the association between FF-MAS oxysterol activity in folliculogenesis and the Hedgehog signaling pathway has not been revealed.
Selim Zırh, Elham Bahador Zırh, Süleyman Erol, Lale Karakoç Sökmensüer, Gürkan Bozdağ, Sevda Fatma Müftüoğlu   +5 more
doaj   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction

Neural Regeneration Research
Recent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment. However, little is known about how fibrosis is induced and regulated after cerebral ischemic injury.
Jun Wen, Hao Tang, Mingfen Tian, Ling Wang, Qinghuan Yang, Yong Zhao, Xuemei Li, Yu Ren, Jiani Wang, Li Zhou, Yongjun Tan, Haiyun Wu, Xinrui Cai, Yilin Wang, Hui Cao, Jianfeng Xu, Qin Yang   +16 more
doaj   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

TARGETING HEDGEHOG PATHWAY SIGNALING IN RENAL CANCER CELLS LINES: A CANCER STEM CELL PERSPECTIVE

, 2013
The purpose of this study is to confirm the presence and expression of Hedgehog Pathway genes and to determine the effects of inhibition of the Hedgehog Pathway on renal cancer cells. RNA from the chosen renal cancer cell lines will be isolated, and real
Borjas, Yves A.
core   +1 more source

Multitarget hedgehog pathway inhibitors and uses thereof

, 2014
The present invention concerns compds. that selectively inhibit the activity of the Hedgehog (Hh) pathway, their prepn. and uses thereof. The compds. of the present invention are useful in treating Hh-​dependent tumors, such as medulloblastoma (MB)​
Mori, Mattia, Toscano, Sara, Infante, Paola, Ingallina, Cinzia, By Botta, Bruno, Gulino, Alberto, Di Marcotullio, Lucia, Ghirga, Francesca, BOTTA, MAURIZIO, Alfonsi, Romina   +9 more
core   +1 more source

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source

Development of a fine-gene hedgehog signature as a patient preselection tool for hedgehog pathway-targeted therapy in medulloblastoma

, 2013
Development of a fine-gene hedgehog signature as a patient preselection tool for hedgehog pathway-targeted therapy in ...
D Amakye (13667071), D Ashley (12372034), A Thomas (841916), K Rose (13467516), D Robinson (9523037), T MacDonald (9209000), E Bouffet (13691014), Y-J Cho (13697503), J Chisholm (13439805), D Hargrave (13667089), M Casanova (13667092), J Heath (13658152), J Rodon (7806563), M Kieran (13697506), KL Ligon (9903048), B Geoerger (13667083), Y Ando (13667080), H Tawbi (11743025), F Doz (13667086), T Sharp (7704572), A Mita (13667095), AA Brandes (14538095)   +21 more
core  

Multi‐Omics Analysis Reveals Coordinated Adaptations in Genes, Metabolism, and Gut Microbiota Underpinning Herbivory in Lordiphosa Flies

Integrative Zoology, EarlyView.
Multi‐omics analysis reveals that herbivorous adaptation in Lordiphosa flies arises from coordinated interactions across the genome, transcriptome, and gut microbiota: genomic expansions of detoxification (e.g., cytochrome P450s) and carbohydrate metabolism gene families, transcriptomic upregulation of energy pathways like lipid oxidation and ...
Run Guo, Jianjun Gao, Caixian Zhang, Zhiheng Chang, Yanbo Sun   +4 more
wiley   +1 more source