Results 201 to 210 of about 58,440 (262)

Pan‐TRK expression and NTRK gene aberrations in meningiomas: association with tumor grade and proliferative activity

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Tropomyosin receptor kinase (TRK) fusions are actionable oncogenic drivers, and pan‐TRK immunohistochemistry (IHC) serves as a reliable screening tool for NTRK gene aberrations. However, the expression profile and clinical significance of pan‐TRK in meningiomas remain unclear.
Yinan Zhu, Mingfang Sun, Wanchen Lu, Ziyue Wang, Haiyan Xi, Yan Song, Hongtao Xu, Xuyong Lin   +7 more
wiley   +1 more source

Imperatorin Suppresses Aberrant Hedgehog Pathway and Overcomes Smoothened Antagonist Resistance via STAT3 Inhibition. [PDF]

Drug Des Devel Ther
Wang J, Cheng H, Zhao X, Zhang X, Ding X, Huang T.   +5 more
europepmc   +1 more source

Primary cilia–extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract Alzheimer's disease (AD) is a neurodegenerative condition marked by cognitive decline and synaptic issues. Recent studies show primary cilia (PCs), sensory organelles present on the surface of most mammalian cells, act as a critical regulators of brain homeostasis and signaling.
Vishal Singh Guleria, Charisse N. Winston   +1 more
wiley   +1 more source

Tai/NCOA2 suppresses the Hedgehog pathway by directly targeting the transcription factor Ci/GLI. [PDF]

Proc Natl Acad Sci U S A
Yu X, Wang X, Ma K, Gao D, Deng Y, Zhou D, Ding W, Zhao Y, Liu Q, Zhou Z.   +9 more
europepmc   +1 more source

A living biobank of sarcoma patient‐derived cell cultures reveals multi‐omic and functional insights that capture disease heterogeneity

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Preclinical models for sarcoma that preserve tumour biology are urgently needed to advance mechanistic understanding and functional precision oncology. 29 early‐passage patient‐derived sarcoma cell (PDC) cultures from 19 patients, representing 11 sarcoma subtypes were established and extensively characterized.
Stefanie Gijsels, Suzanne Fischer, David Creytens, Sándor Dedeyne, Felix De Vuyst, Cláudio Pinheiro, Fleur Cordier, Sarah‐Lee Bekaert, Nadine Van Roy, Kaat Durinck, Jarne Pauwels, Kris Gevaert, Pieter Mestdagh, Jo Vandesompele, Pekka Rappu, Jyrki Heino, An Hendrix, Gabrielle H. van Ramshorst, Gwen Sys, Olivier De Wever   +19 more
wiley   +1 more source

Negative feedback between PTH1R and IGF1 through the Hedgehog pathway in mediating craniofacial bone remodeling. [PDF]

JCI Insight
Fan Y, Lyu P, Wang J, Wei Y, Li Z, Zhang S, Ouchi T, Jing J, Yuan Q, Rosen CJ, Zhou C.   +10 more
europepmc   +1 more source

Regulators of Wnt Signaling Dkk‐1 and Notum Are Elevated in Pediatric ADHD

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Wnt signaling has increasingly drawn attention in discussions of ADHD, yet the peripheral status of its upstream regulators remains largely uncharted. In this study, we examined circulating levels of four key modulators of this pathway—Dkk‐1, PORCN, Notum, and Tiki‐1—in a sample of children and adolescents with an ADHD diagnosis.
Fatma Coşkun, Ayşegül Metin Emre, İbrahim Kılınç, Ahmet Osman Kılıç   +3 more
wiley   +1 more source

Clinical and Histological Predictors of Advanced Basal Cell Carcinoma Recurrence After Complete Response to Hedgehog Pathway Inhibitors: A Retrospective Multicenter Observational Study. [PDF]

Cancers (Basel)
Mannino M, Scalvenzi M, Di Stefani A, Costa C, Calzavara-Pinton P, Fargnoli MC, Piccerillo A, Bocchino E, Zalaudek I, Ascierto PA, Quaglino P, Queirolo P, Dika E, De Giorgi V, Moscarella E, Bianchi L, Longo C, Cantisani C, Villani A, Peris K, Collaborators.   +20 more
europepmc   +1 more source

Understanding Barriers to Human‐Wildlife Coexistence: Evidence From Southern Sri Lanka

Ecology and Evolution, Volume 16, Issue 7, July 2026.
We investigated the barriers to coexistence with wild elephants (Elephas maximus maximus) as experienced by farmer communities in Southern Sri Lanka. Through an ethnographic study, we identified socio‐political drivers, institutional and structural challenges, and power and corruption as the main themes of barriers to coexistence.
Anuradhi Dulangi Jayasinghe, Georgette Leah Burns, Duan Biggs   +2 more
wiley   +1 more source

Pharmacology of Veratrum californicum Alkaloids as Hedgehog Pathway Antagonists. [PDF]

Pharmaceuticals (Basel)
Dirks ML, McDougal OM.
europepmc   +1 more source