Results 201 to 210 of about 1,302,226 (294)

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Eight-Year Experience of Hedgehog Pathway Inhibitors at Three Tertiary Referral Centres in the Australian State of Victoria. [PDF]

Australas J Dermatol
Gan C, Manuelpillai N, Foley P, McCormack C, Goh MS.   +4 more
europepmc   +1 more source

Bioinformatics Identification of lncRNA‐Associated Molecular Signatures Potentially Related to Quercetin Response in Breast Cancer

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Breast cancer affects approximately one in every eight women globally, as reported by the World Health Organization. Among all female malignant tumors, breast cancer has the highest fatality rate, surpassed only by lung cancer. Advanced stages of this disease are almost always fatal, and despite the advancements in surgical techniques and ...
Mahboobeh Mehrabani Natanzi, Zohreh Khodaii, Naghmeh Zhalehjoo   +2 more
wiley   +1 more source

Selective EV Protein Sorting and Pathway Perturbation in AML Upon Synergistic FLT3 and Hedgehog Pathway Inhibition. [PDF]

J Extracell Vesicles
Blöchl C, Blümel G, Wolf M, Regl C, Binder HM, Tesanovic S, Lankes D, Maeding N, Krenn PW, Strunk D, Aberger F, Huber CG.   +11 more
europepmc   +1 more source

β‐Arrestin1 Promotes Prostate Cancer Progression via Modulating ESRP1‐Mediated Alternative Splicing of CD44

MedComm – Oncology, Volume 5, Issue 4, December 2026.
β‐arrestin1 promotes prostate cancer progression by suppressing epithelial splicing regulatory protein 1 (ESRP1) expression and shifting CD44 alternative splicing toward CD44s and away from CD44v2 and CD44v6. These changes accompany increased N‐cadherin, decreased E‐cadherin, and enhanced epithelial–mesenchymal transition.
Sicheng Dong, Minlian Pan, Zhiqing He, Cong Wang, Yuhao Zhou, Jiayin Du, Tianyu Huang, Xue Wang, Xiaofeng Zhou, Zhixiong Zhang, Di Gu, Xiaolu Duan, Mengping Zhang   +12 more
wiley   +1 more source

Glypican-3 is a key tuner of the Hedgehog pathway in COPD. [PDF]

Heliyon
Petit LMG, Saber Cherif L, Devilliers MA, Hatoum S, Ancel J, Delepine G, Durlach A, Dubernard X, Mérol JC, Ruaux C, Polette M, Deslée G, Perotin JM, Dormoy V.   +13 more
europepmc   +1 more source

Depicting the Immunological Landscape of Basal Cell Carcinoma Subtypes

Journal of Cutaneous Pathology, Volume 53, Issue 12, Page 1131-1141, December 2026.
ABSTRACT Background Anti‐PD‐1 response has been associated with higher PD‐1 ligand (PD‐L1) expression levels in different cancer types. Cemiplimab, an anti‐PD‐1 antibody, has been shown to induce a response rate of 31% and 22% in patients with locally advanced basal cell carcinoma (BCC) and metastatic BCC respectively, who have progressed or are ...
Isabella Dommann, Gaetana Restivo, Isabel Kolm, Federica Sella, Patrick Turko, Phil F. Cheng, Mitchell Levesque, Corina Dommann‐Scherrer, Reinhard Dummer, Egle Ramelyte   +9 more
wiley   +1 more source

Hedgehog Pathway Mutation [PDF]

, 2020
openaire   +1 more source

Caudal fin shape imprinted during late zebrafish embryogenesis is re-patterned by the Sonic hedgehog pathway. [PDF]

PLoS Biol
Surette E, Donahue J, Soto Martinez C, Robinson S, McKenna D, Fitzgerald B, Backus K, Karlstrom RO, Cumplido N, McMenamin SK.   +9 more
europepmc   +1 more source