Results 201 to 210 of about 58,542 (264)

miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC models

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Dysfunctional microRNAs and GABAergic interneurons are features of Alzheimer's disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown. METHODS We utilized in silico analyses of published databases, MIR155‐deleted and ‐overexpressing human induced pluripotent stem cell ...
Xiaodong Zhu, Jean‐Vianney Haure‐Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al‐subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E. Ehrlich   +10 more
wiley   +1 more source

Pharmacology of Veratrum californicum Alkaloids as Hedgehog Pathway Antagonists. [PDF]

Pharmaceuticals (Basel)
Dirks ML, McDougal OM.
europepmc   +1 more source

Evaluation of IHH, PTCH1, and SMO protein immunohistochemistry in the human mandibular condyle at fetal stages from 30 to 80 mm greatest length

The Anatomical Record, Volume 309, Issue 8, Page 2176-2188, August 2026.
Abstract This study evaluated the morphogenesis of the temporomandibular joint (TMJ) in human fetuses during the third month of gestation through the analysis of immunohistochemistry for the proteins Indian Hedgehog (IHH), Patched‐1 (PTCH1), and Smoothened (SMO).
Filipe Santos da Silva, Carolina de Oliveira Gigek, Andreia Fabiana Do Vale Franco, Amanda Alves Ribeiro Massoni, José Ramon Mérida‐Velasco, Luís Otávio Carvalho de Moraes   +5 more
wiley   +1 more source

Clinical and Histological Predictors of Advanced Basal Cell Carcinoma Recurrence After Complete Response to Hedgehog Pathway Inhibitors: A Retrospective Multicenter Observational Study. [PDF]

Cancers (Basel)
Mannino M, Scalvenzi M, Di Stefani A, Costa C, Calzavara-Pinton P, Fargnoli MC, Piccerillo A, Bocchino E, Zalaudek I, Ascierto PA, Quaglino P, Queirolo P, Dika E, De Giorgi V, Moscarella E, Bianchi L, Longo C, Cantisani C, Villani A, Peris K, Collaborators.   +20 more
europepmc   +1 more source

Single‐Cell RNA Sequencing Reveals Disrupted Stromal–Epithelial Crosstalk Impairs Gut Barrier in Depression

Brain and Behavior, Volume 16, Issue 8, August 2026.
scRNA‐seq atlas of the depressed mouse colon reveals that expansion of disease‐specific cCF1 and CTF stromal subsets disrupts epithelial homeostasis via enhanced TGF‐ß and suppressed WNT/ß‐catenin signaling, impairing stem cell function, differentiation, and intestinal barrier integrity.
Xiao‐Song Xu, Wan‐Ning Zhang, Xu‐Rui Hao, Xiao‐Yu Liu, Hong‐Chen Yu, Cai‐Xia Jia, Jian‐Ming Jiang, De‐Zhi Kong, Yan‐Ru Cai   +8 more
wiley   +1 more source

A Pilot Immunohistochemical Study Identifies Hedgehog Pathway Expression in Sinonasal Adenocarcinoma. [PDF]

Int J Mol Sci
Leović M, Jakovčević A, Mumlek I, Zagorac I, Sabol M, Leović D.   +5 more
europepmc   +1 more source

Targeting Spatiotemporal Heterogeneity of oncomiRNAs: A New Frontier in Cancer Therapy

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background miRNAs are short RNA transcripts that modulate gene expression after transcription and have emerged as pivotal regulators of cancer biology. A subset, termed oncomiRNAs, functions as oncogenes or tumor suppressors, influencing key cellular events such as cell growth, programmed cell death, neovascularization, tissue invasion, and ...
T. Jeethy Ram, Muralee Damodaran
wiley   +1 more source

Applying Spinal Cord Organoids as a quantitative approach to study the mammalian Hedgehog pathway. [PDF]

PLoS One
Holzner M, Wutz A, Di Minin G.
europepmc   +1 more source

From scarring to healing: Emerging regenerative therapies for pulmonary fibrosis using MSCs and exosomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
MSCs exert anti‐inflammatory, anti‐fibrotic and regenerative effects in pulmonary fibrosis. MSC‐derived exosomes reproduce many therapeutic benefits of parental MSCs. Preconditioning and genetic modification improve MSC therapeutic performance. Current preclinical and clinical evidence supports the translational potential of MSC‐based therapies ...
Hajar Nasiri, Farbod Khosravi, Fatemeh Eskandari, Tahereh Manoochehrabadi, Ali Samadikuchaksaraei, Ehsan Lotfi, Jila Majidi, Fatemeh Rafati, Zeynab Ghorbani   +8 more
wiley   +1 more source

Examination of piperonyl butoxide developmental toxicity as a Sonic hedgehog pathway inhibitor targeting limb and palate morphogenesis. [PDF]

Reprod Toxicol
Rivera-González KS, Reynolds PM, Lipinski RJ.   +2 more
europepmc   +1 more source