Results 221 to 230 of about 58,542 (264)
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Hedgehog-GLI Pathway in Medulloblastoma
Journal of Clinical Oncology, 2012Medulloblastoma (MB), the most common malignant brain tumor in children, arises in the cerebellum. Aberrant activation of the sonic hedgehog (SHH) pathway has been unambiguously tied to the etiology of one subtype of the disease. Although the majority of tumors arise through somatic mutations, familial predisposition to MB is well known to occur in ...
Tenley C, Archer +2 more
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THE HEDGEHOG PATHWAY AND NEUROLOGICAL DISORDERS
Annual Review of Neuroscience, 2006The hedgehog pathway is a major regulator of embryonic development, and mutations that decrease its activity are known to be associated with severe defects in nervous system development. Recent evidence suggests hedgehog continues to function in adult tissue, normal as well as diseased, by regulating both cell proliferation and the production of ...
Tammy, Dellovade +3 more
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The Hedgehog Pathway and Pancreatic Cancer
New England Journal of Medicine, 2009Treatment of a mouse model of aggressive pancreatic cancer with an inhibitor of the hedgehog pathway enhanced tumor sensitivity to gemcitabine and resulted in the stabilization of disease.
Manuel, Hidalgo, Anirban, Maitra
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The Hedgehog Signaling Pathway in Cancer
2005The Hedgehog (Hh) signaling pathway plays crucial roles during embryonic development, where it controls cell proliferation, differentiation, and tissue patterning in numerous tissues and organs (Ingham and McMahon 2001; Cohen 2003). Mutations in genes encoding key members of the pathway can result in many human developmental disorders, including ...
Janni, Vestergaard +2 more
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Hijacking the Hedgehog Pathway in Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry, 2016The hedgehog (Hh) signaling pathway, which is almost completely silenced in normal adult tissues but highly activated in cancer, offers ideal drug targets for small molecule development. During the last few years, several studies have indicated that the Hh pathway plays a role in tumor development and maintenance, and novel drugs inhibiting Hh ...
Laukkanen M, Castellone M
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The Hedgehog signalling pathway and cancer
The Journal of Pathology, 2001The Hedgehog signalling pathway is important in embryological development and is highly conserved through evolution. Recently Patched, a member of the pathway, was found to be important in Gorlin's syndrome. Inherited Patched gene mutations underlie the syndrome, in which a key feature is multiple basal cell carcinomas (BCCs).
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Potent Inhibitors of the Hedgehog Signaling Pathway
Journal of Medicinal Chemistry, 2008A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.
Shirley A, Brunton +6 more
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Hedgehog Signaling Pathway in Drosophila
Science's STKE, 2007Studies in Drosophila have provided the framework for understanding human development and disease processes governed by the Hedgehog (Hh) family of secreted signaling molecules. The Drosophila proteins that participate in Hh-mediated signal transduction are highlighted in a Connections Map ...
Leni, Jacob, Lawrence, Lum
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2009
The Hedgehog (Hh) Pathway, originally identified in Drosophila, [1–4] is a highly conserved signaling pathway which orchestrates multiple, disparate aspects of embryogenesis, development and tissue remodeling in a wide spectrum of systems [5–8]. This is usually accomplished by autocrine/paracrine signaling and aims to control the size and localization ...
Alessia Omenetti, Anna Mae Diehl
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The Hedgehog (Hh) Pathway, originally identified in Drosophila, [1–4] is a highly conserved signaling pathway which orchestrates multiple, disparate aspects of embryogenesis, development and tissue remodeling in a wide spectrum of systems [5–8]. This is usually accomplished by autocrine/paracrine signaling and aims to control the size and localization ...
Alessia Omenetti, Anna Mae Diehl
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The Hedgehog Pathway: Revisited
Dermatologic Surgery, 2004Thomas C, Yu, Stanley J, Miller
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