Results 221 to 230 of about 1,302,226 (294)

Mechanisms of Tumor Cell Invasion: Insights From the Perspective of Epithelial‐to‐Mesenchymal Transition

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Tumor invasion implies aberrantly increased cell motility, and is the first step of the cascade of events culminating in the development of distant metastases. The emergence of migratory capacity in epithelial carcinomas, consisting essentially of stationary cells, is linked to the activation of the epithelial‐to‐mesenchymal transition (EMT ...
Marcello Guarino
wiley   +1 more source

Stabilization of OLFML1 via m⁶A Reader IGF2BP3 Drives CSC Characteristics Through Hedgehog Pathway Activation in CRC. [PDF]

Int J Biol Sci
Zhong Y, Liu J, Lin W, Peng T, Gao L, Shen L, Wang P, Hu Z, Long T, Li Z, Liu J.   +10 more
europepmc   +1 more source

The Potential Role of Gut Microbiome Dysbiosis and Functional Reprogramming in Colorectal Liver Metastasis via the Gut–Liver Axis

Cancer Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background Colorectal liver metastasis (CRLM) is a leading cause of mortality in colorectal cancer (CRC), yet current surveillance often misses occult micrometastases, underscoring an urgent need for early non‐invasive biomarkers and mechanistic insights.
Yuejin Sheng, Xiaoyu Dai, Jiaqi Lu, Hao Zhang, Ping Cai   +4 more
wiley   +1 more source

RETRACTION: TMEM107 Inhibits EMT and Invasion of NSCLC Through Regulating the Hedgehog Pathway. [PDF]

Thorac Cancer
europepmc   +1 more source

Hedgehog Pathway Is a Regulator of Stemness in HER2-Positive Trastuzumab-Resistant Breast Cancer. [PDF]

Int J Mol Sci
Er I, Boz Er AB.
europepmc   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1301-1314, November 2026.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Dual Targeting of Smoothened, a Key Regulator in the Hedgehog Pathway, and BCR-ABL1 Effectively Eradicates Drug-Insensitive Stem/Progenitor Cells in Chronic Myeloid Leukemia. [PDF]

Cells
Turner KA, Chen M, Rothe K, Forrest DL, Jiang X.   +4 more
europepmc   +1 more source

LncRNA A1BGAS1 Serves as a Tumor Suppressor in Non‐Small Cell Lung Cancer by Modulating the Expression of miR‐3942‐5P

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
This study verified the potential of A1BG‐AS1 to serve as a molecular biomarker for NSCLC prognosis. Mechanistically, A1BG‐AS1 exerts inhibitory effects on NSCLC cell proliferation, migration, and invasion and exerts a promoting effect on apoptosis via direct targeting and downregulation of miR‐3942‐5p.
Jiahui Du, Zhenhua Li, Chunqiang Wang, Xuexi Zhang   +3 more
wiley   +1 more source

GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway. [PDF]

J Exp Clin Cancer Res
Tang C, Li L, Zhu C, Xu Q, An Z, Xu S, Lin C.   +6 more
europepmc   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, Volume 6, Issue 11, Page 473-489, November 2026.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source