Results 241 to 250 of about 1,302,226 (294)

Tai/NCOA2 suppresses the Hedgehog pathway by directly targeting the transcription factor Ci/GLI. [PDF]

Proc Natl Acad Sci U S A
Yu X, Wang X, Ma K, Gao D, Deng Y, Zhou D, Ding W, Zhao Y, Liu Q, Zhou Z.   +9 more
europepmc   +1 more source

Negative feedback between PTH1R and IGF1 through the Hedgehog pathway in mediating craniofacial bone remodeling. [PDF]

JCI Insight
Fan Y, Lyu P, Wang J, Wei Y, Li Z, Zhang S, Ouchi T, Jing J, Yuan Q, Rosen CJ, Zhou C.   +10 more
europepmc   +1 more source

A Pilot Immunohistochemical Study Identifies Hedgehog Pathway Expression in Sinonasal Adenocarcinoma. [PDF]

Int J Mol Sci
Leović M, Jakovčević A, Mumlek I, Zagorac I, Sabol M, Leović D.   +5 more
europepmc   +1 more source

Clinical and Histological Predictors of Advanced Basal Cell Carcinoma Recurrence After Complete Response to Hedgehog Pathway Inhibitors: A Retrospective Multicenter Observational Study. [PDF]

Cancers (Basel)
Mannino M, Scalvenzi M, Di Stefani A, Costa C, Calzavara-Pinton P, Fargnoli MC, Piccerillo A, Bocchino E, Zalaudek I, Ascierto PA, Quaglino P, Queirolo P, Dika E, De Giorgi V, Moscarella E, Bianchi L, Longo C, Cantisani C, Villani A, Peris K, Collaborators.   +20 more
europepmc   +1 more source

Applying Spinal Cord Organoids as a quantitative approach to study the mammalian Hedgehog pathway. [PDF]

PLoS One
Holzner M, Wutz A, Di Minin G.
europepmc   +1 more source

Examination of piperonyl butoxide developmental toxicity as a Sonic hedgehog pathway inhibitor targeting limb and palate morphogenesis. [PDF]

Reprod Toxicol
Rivera-González KS, Reynolds PM, Lipinski RJ.   +2 more
europepmc   +1 more source

Modulating the Hedgehog pathway

, 2013
openaire   +2 more sources

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Targeting the Hedgehog Pathway in Cancer

Nature Reviews Drug Discovery, 2006
Several key signalling pathways, such as Hedgehog, Notch, Wnt and BMP-TGFbeta-Activin (bone morphogenetic protein-transforming growth factor-beta-Activin), are involved in most processes essential to the proper development of an embryo. It is also becoming increasingly clear that these pathways can have a crucial role in tumorigenesis when reactivated ...
Frederic J de Sauvage, Lee L. Rubin, De Sauvage Frederic J   +2 more
exaly   +3 more sources

The Hedgehog Pathway and Pancreatic Cancer

New England Journal of Medicine, 2009
Treatment of a mouse model of aggressive pancreatic cancer with an inhibitor of the hedgehog pathway enhanced tumor sensitivity to gemcitabine and resulted in the stabilization of disease.
Anirban Maitra, Manuel Hidalgo
exaly   +3 more sources

Hunting the Hedgehog Pathway

Clinical Pharmacology & Therapeutics, 2010
Since the observation nearly 50 years ago of cyclopic newborn lambs borne by ewes grazing on California corn lily, an explosion of discovery has ensued. The Hedgehog (HH) signaling pathway is perhaps one of the most exciting targets in cancer research today.
G J, Weiss, D D, Von Hoff
openaire   +2 more sources