Results 231 to 240 of about 58,440 (262)
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Hijacking the Hedgehog Pathway in Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry, 2016The hedgehog (Hh) signaling pathway, which is almost completely silenced in normal adult tissues but highly activated in cancer, offers ideal drug targets for small molecule development. During the last few years, several studies have indicated that the Hh pathway plays a role in tumor development and maintenance, and novel drugs inhibiting Hh ...
Laukkanen M, Castellone M
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The Hedgehog signalling pathway and cancer
The Journal of Pathology, 2001The Hedgehog signalling pathway is important in embryological development and is highly conserved through evolution. Recently Patched, a member of the pathway, was found to be important in Gorlin's syndrome. Inherited Patched gene mutations underlie the syndrome, in which a key feature is multiple basal cell carcinomas (BCCs).
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Potent Inhibitors of the Hedgehog Signaling Pathway
Journal of Medicinal Chemistry, 2008A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.
Shirley A, Brunton +6 more
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Hedgehog Signaling Pathway in Drosophila
Science's STKE, 2007Studies in Drosophila have provided the framework for understanding human development and disease processes governed by the Hedgehog (Hh) family of secreted signaling molecules. The Drosophila proteins that participate in Hh-mediated signal transduction are highlighted in a Connections Map ...
Leni, Jacob, Lawrence, Lum
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The Hedgehog and Wnt signalling pathways in cancer
Nature, 2001The Wnt and Hedgehog (Hh) signalling pathways have long been known to direct growth and patterning during embryonic development. Recent evidence also implicates these pathways in the postembryonic regulation of stem-cell number in epithelia such as those of the skin and intestine, which undergo constant renewal.
J, Taipale, P A, Beachy
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Functional role of hedgehog pathway in osteoarthritis
Cell Biochemistry and Function, 2019The hedgehog signalling pathway is one of the key regulators of metazoan development, and it plays an important role in the regulation of a variety of developmental and physiological processes. But it is aberrantly activated in many human diseases, including osteoarthritis (OA).
Wen‐feng Xiao +4 more
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2009
The Hedgehog (Hh) Pathway, originally identified in Drosophila, [1–4] is a highly conserved signaling pathway which orchestrates multiple, disparate aspects of embryogenesis, development and tissue remodeling in a wide spectrum of systems [5–8]. This is usually accomplished by autocrine/paracrine signaling and aims to control the size and localization ...
Alessia Omenetti, Anna Mae Diehl
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The Hedgehog (Hh) Pathway, originally identified in Drosophila, [1–4] is a highly conserved signaling pathway which orchestrates multiple, disparate aspects of embryogenesis, development and tissue remodeling in a wide spectrum of systems [5–8]. This is usually accomplished by autocrine/paracrine signaling and aims to control the size and localization ...
Alessia Omenetti, Anna Mae Diehl
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The Hedgehog Pathway: Revisited
Dermatologic Surgery, 2004Thomas C, Yu, Stanley J, Miller
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Reactome - a curated knowledgebase of biological pathways, 2006
D Kalderon, MG Williams
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D Kalderon, MG Williams
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