Results 231 to 240 of about 1,302,226 (294)

In vivo sonic hedgehog pathway antagonism temporarily results in ancestral proto-feather-like structures in the chicken. [PDF]

PLoS Biol
Cooper RL, Milinkovitch MC.
europepmc   +1 more source

Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL‐KrasG12D/+; p48Cre/+ Mice

Molecular Carcinogenesis, Volume 65, Issue 11, Page 1383-1397, November 2026.
ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata, Deepanshi Dhar, Rama Kant, Robin Kumar, Md. Imtiazul Kabir, Chapla Agarwal, Rajesh Agarwal, Komal Raina   +7 more
wiley   +1 more source

Curcumin and Methotrexate: A Promising Combination for Osteosarcoma Treatment via Hedgehog Pathway Inhibition. [PDF]

Int J Mol Sci
Giliberti G, Marrapodi MM, Di Feo G, Pota E, Di Martino M, Di Pinto D, Rossi F, Di Paola A.   +7 more
europepmc   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Synthesis and Evaluation of Aromatic A-Ring 23-Oxavitamin D₃ Analogues as Hedgehog Pathway Inhibitors. [PDF]

Int J Mol Sci
Chen W, Lai F, Xu J.
europepmc   +1 more source

Liver Injury Repair and Regeneration: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 11, November 2026.
This review outlines the spatiotemporal framework of liver injury repair and regeneration, orchestrated by molecular signaling, multicellular niche crosstalk, metabolic reprogramming, and interorgan communication. Post‑injury regenerative cascades (initiation, proliferation, termination) rely on crosstalk between hepatocytes, Kupffer cells, hepatic ...
Mingyue Pan, Ni An, Yutian Feng, Yuelei Hu, Chongqin Pan, Yuxin Su, Yuanzheng Huang, Tanqing Long, Qi Wang, Qingru Song, Pengfei Li, Xiaomeng Li, Wenzhen Yin, Zhiyuan Hu, Xiaoxuan Liu, Juan Liu   +15 more
wiley   +1 more source

Pharmacology of Veratrum californicum Alkaloids as Hedgehog Pathway Antagonists. [PDF]

Pharmaceuticals (Basel)
Dirks ML, McDougal OM.
europepmc   +1 more source

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

Imperatorin Suppresses Aberrant Hedgehog Pathway and Overcomes Smoothened Antagonist Resistance via STAT3 Inhibition. [PDF]

Drug Des Devel Ther
Wang J, Cheng H, Zhao X, Zhang X, Ding X, Huang T.   +5 more
europepmc   +1 more source

Human–wildlife coexistence and social context: Evidence from farmer communities in southern Sri Lanka

People and Nature, Volume 8, Issue 11, Page 4026-4040, November 2026.
Abstract Studies on human–wildlife interactions (HWI) often focus on conflict mitigation studies, thus overlooking underlying factors that influence community decisions to coexist with wildlife. To address this knowledge gap, we collected empirical evidence of how community interactions with wildlife are shaped by their social contexts.
Anuradhi Dulangi Jayasinghe, Georgette Leah Burns, Johanna Nalau, Duan Biggs   +3 more
wiley   +1 more source