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Science's STKE, 2007
The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.
Leni, Jacob, Lawrence, Lum
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The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.
Leni, Jacob, Lawrence, Lum
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Tuning the Hedgehog Pathway [PDF]
Nature Reviews Molecular Cell Biology, 2012 Maria Papatriantafyllou
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Modulators of the hedgehog signaling pathway
Bioorganic & Medicinal Chemistry, 2010Since its discovery by C. Nüsslein-Volhard and E. F. Wieschaus, hedgehog (hh) signaling has come a long way. Today it is regarded as a key regulator in embryogenesis where it governs processes like cell proliferation, differentiation, and tissue patterning. Furthermore, in adults it is involved in the maintenance of stem cells, and in tissue repair and
Philipp, Heretsch +2 more
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Hedgehog-GLI Pathway in Medulloblastoma
Journal of Clinical Oncology, 2012Medulloblastoma (MB), the most common malignant brain tumor in children, arises in the cerebellum. Aberrant activation of the sonic hedgehog (SHH) pathway has been unambiguously tied to the etiology of one subtype of the disease. Although the majority of tumors arise through somatic mutations, familial predisposition to MB is well known to occur in ...
Tenley C, Archer +2 more
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THE HEDGEHOG PATHWAY AND NEUROLOGICAL DISORDERS
Annual Review of Neuroscience, 2006The hedgehog pathway is a major regulator of embryonic development, and mutations that decrease its activity are known to be associated with severe defects in nervous system development. Recent evidence suggests hedgehog continues to function in adult tissue, normal as well as diseased, by regulating both cell proliferation and the production of ...
Tammy, Dellovade +3 more
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The Hedgehog Signaling Pathway in Cancer
2005The Hedgehog (Hh) signaling pathway plays crucial roles during embryonic development, where it controls cell proliferation, differentiation, and tissue patterning in numerous tissues and organs (Ingham and McMahon 2001; Cohen 2003). Mutations in genes encoding key members of the pathway can result in many human developmental disorders, including ...
Janni, Vestergaard +2 more
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Hijacking the Hedgehog Pathway in Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry, 2016The hedgehog (Hh) signaling pathway, which is almost completely silenced in normal adult tissues but highly activated in cancer, offers ideal drug targets for small molecule development. During the last few years, several studies have indicated that the Hh pathway plays a role in tumor development and maintenance, and novel drugs inhibiting Hh ...
Laukkanen M, Castellone M
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The Hedgehog signalling pathway and cancer
The Journal of Pathology, 2001The Hedgehog signalling pathway is important in embryological development and is highly conserved through evolution. Recently Patched, a member of the pathway, was found to be important in Gorlin's syndrome. Inherited Patched gene mutations underlie the syndrome, in which a key feature is multiple basal cell carcinomas (BCCs).
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Potent Inhibitors of the Hedgehog Signaling Pathway
Journal of Medicinal Chemistry, 2008A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.
Shirley A, Brunton +6 more
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Hedgehog Signaling Pathway in Drosophila
Science's STKE, 2007Studies in Drosophila have provided the framework for understanding human development and disease processes governed by the Hedgehog (Hh) family of secreted signaling molecules. The Drosophila proteins that participate in Hh-mediated signal transduction are highlighted in a Connections Map ...
Leni, Jacob, Lawrence, Lum
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