Results 211 to 220 of about 58,542 (264)

Identification of novel genes regulating the development of the palate

Developmental Dynamics, Volume 255, Issue 8, Page 808-823, August 2026.
Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley   +1 more source

Unravelling the Mysteries of the Sonic Hedgehog Pathway in Cancer Stem Cells: Activity, Crosstalk and Regulation. [PDF]

Curr Issues Mol Biol
Berrino C, Omar A.
europepmc   +1 more source

Localized application of SAG21k-loaded fibrin hydrogels for targeted modulation of the hedgehog pathway in facial nerve injury. [PDF]

Int J Biol Macromol
He L, Sato JE, Sundar P, Azimi T, Beachy PA, Bekale LA, Pepper JP.   +6 more
europepmc   +1 more source

Noncanonical UPR factor CREB3L2 drives immune evasion of triple-negative breast cancer through Hedgehog pathway modulation in T cells. [PDF]

Sci Adv
Cao ZJ, You J, Fan YM, Yang JY, Sun J, Ma X, Zhang J, Li Z, Wang X, Feng YX.   +9 more
europepmc   +1 more source

Modulating the Hedgehog pathway

, 2013
openaire   +2 more sources

Hedgehog Signaling Pathway in Ovarian Cancer [PDF]

International Journal of Molecular Sciences, 2013
Despite advances in surgical and chemotherapeutic treatment options, less than 50% of patients with advanced-stage ovarian cancer survive five years after initial diagnosis. In this regard, novel treatment approaches are warranted utilizing molecularly targeted therapies directed against particular components of specific signaling pathways which are ...
Tobias Kiesslich, Johannes Haybaeck, Joanna Szkandera   +2 more
exaly   +4 more sources

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Hunting the Hedgehog Pathway

Clinical Pharmacology & Therapeutics, 2010
Since the observation nearly 50 years ago of cyclopic newborn lambs borne by ewes grazing on California corn lily, an explosion of discovery has ensued. The Hedgehog (HH) signaling pathway is perhaps one of the most exciting targets in cancer research today.
G J, Weiss, D D, Von Hoff
openaire   +2 more sources

Hedgehog Signaling Pathway

Science's STKE, 2007
The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.
Leni, Jacob, Lawrence, Lum
openaire   +2 more sources

Targeting the Hedgehog pathway in cancer

Nature Reviews Drug Discovery, 2006
Several key signalling pathways, such as Hedgehog, Notch, Wnt and BMP-TGFbeta-Activin (bone morphogenetic protein-transforming growth factor-beta-Activin), are involved in most processes essential to the proper development of an embryo. It is also becoming increasingly clear that these pathways can have a crucial role in tumorigenesis when reactivated ...
Lee L, Rubin, Frederic J, de Sauvage
openaire   +2 more sources

Modulators of the hedgehog signaling pathway

Bioorganic & Medicinal Chemistry, 2010
Since its discovery by C. Nüsslein-Volhard and E. F. Wieschaus, hedgehog (hh) signaling has come a long way. Today it is regarded as a key regulator in embryogenesis where it governs processes like cell proliferation, differentiation, and tissue patterning. Furthermore, in adults it is involved in the maintenance of stem cells, and in tissue repair and
Philipp, Heretsch, Lito, Tzagkaroulaki, Athanassios, Giannis   +2 more
openaire   +2 more sources