Results 41 to 50 of about 2,340,031 (328)

Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas

BMC Veterinary Research, 2023
Background The hedgehog signalling pathway has been implicated in tumourigenesis and progression of many tumour types. This pathway has recently emerged as a therapeutic target, and inhibitors of hedgehog signalling have gained considerable attention. In
Haein Koo, Sungin Lee, Wan Hee Kim
doaj   +1 more source

Some properties of the nematic radial hedgehog in Landau-de Gennes' theory [PDF]

Journal of Mathematical Analysis and applications 397, 2 (2013) pp 586-594, 2012
In the Landau-de Gennes theoretical framework of a $Q -tensor description of nematic liquid crystals, we consider a radial hedgehog defect with strong anchoring conditions in a ball $B \subset \mathbb{R}^3$ . We show that the scalar order parameter is monotonic, and we prove uniqueness of the minimizing hedgehog below the spinodal temperature $T^\ast$ .
arxiv   +1 more source

Gravitational hedgehog, stringy hedgehog and stringy sphere [PDF]

JHEP 0311 (2003) 058, 2003
We investigate the solutions of Einstein equations such that a hedgehog solution is matched to different exterior or interior solutions via a spherical shell. In the case where both the exterior and the interior regions are hedgehog solutions or one of them is flat, the resulting spherical shell becomes a stringy shell.
arxiv   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Stability of the B=2 hedgehog in the Skyrme model [PDF]

Nucl.Phys. A602 (1996) 347-374, 1995
We study the unstable modes of the baryon number two hedgehog of the Skyrme model on a three dimensional spatial lattice. An expansion of the Skyrme Lagrangian around the hedgehog configuration provides the equations of motion for the fluctuation fields solvable numerically via a relaxation method. We find the negative energy modes and, by evolving the
arxiv   +1 more source

Hedgehog-lattice spin texture in classical Heisenberg antiferromagnets on the breathing pyrochlore lattice [PDF]

Phys. Rev. B 103, 014406 (2021), 2020
The hedgehog lattice, a three-dimensional periodic array of magnetic monopoles and antimonopoles, is known to be realized in the presence of the Dzyaloshinskii-Moriya (DM) interaction. Here, we demonstrate by means of Monte Carlo simulations that the hedgehog lattice is induced by not the DM interaction but frustration in classical Heisenberg ...
arxiv   +1 more source

Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease

Cancers, 2021
Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during development and it is commonly dysregulated in many diseases, including cancer.
Ashley N. Sigafoos, Brooke D. Paradise, M. Fernandez-Zapico   +2 more
semanticscholar   +1 more source

The Crosstalk of mTOR/S6K1 and Hedgehog Pathways [PDF]

Cancer Cell, 2012
Esophageal adenocarcinoma (EAC) is the most prevalent esophageal cancer type in the United States. The TNF-α/mTOR pathway is known to mediate the development of EAC. Additionally, aberrant activation of Gli1, downstream effector of the Hedgehog (HH) pathway, has been observed in EAC.
Dung Fang Lee, Dung Fang Lee, Yun Wu, Dongping Liu, Chia Wei Li, Jennifer L. Hsu, Jennifer L. Hsu, Jennifer L. Hsu, Stephanie A. Miller, Chung-Hsuan Chen, Wei Chao Chang, Wei Chao Chang, Kenneth K. Wang, Weiya Xia, Jingyu Lang, Chien-Chen Lai, Chien-Chen Lai, Mien Chie Hung, Yan Wang, Longfei Huo, Xuemei Wang, Navtej S. Buttar, Julie G. Izzo, Tsung Teh Wu, Tzu Hsuan Huang, Jung Mao Hsu, Jung Mao Hsu, Adam M. Labaff, Adam M. Labaff, Qingqing Ding, Chia Jui Yen, Fuu Jen Tsai, Huamin Wang, Jaffer A. Ajani   +33 more
openaire   +3 more sources

On Ramsey numbers of hedgehogs [PDF]

Combinator. Probab. Comp. 29 (2020) 101-112, 2019
The hedgehog $H_t$ is a 3-uniform hypergraph on vertices $1,\dots,t+\binom{t}{2}$ such that, for any pair $(i,j)$ with $1\le it$ such that $\{i,j,k\}$ is an edge. Conlon, Fox, and R\"odl proved that the two-color Ramsey number of the hedgehog grows polynomially in the number of its vertices, while the four ...
arxiv   +1 more source

The hedgehog pathway in breast cancer [PDF]

Chinese Journal of Cancer Research, 2012
Breast cancer is one of the most common cancers around the world with approximately 1.6 million new cases and 425 thousand deaths from the disease in 2010 (1). While early detection methods and treatment have continuously evolved and improved over the years, there is still a strong need to further understand the pathways and mechanisms that lead to and
openaire   +3 more sources