Results 41 to 50 of about 49,844 (160)

Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. [PDF]

, 2016
1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family ...
Bikle, Daniel D, Jiang, Yan, Nguyen, Thai, Oda, Yuko, Tu, Chia-Ling   +4 more
core   +2 more sources

Expression of Sonic Hedgehog and pathway components in the embryonic mouse head: anatomical relationships between regulators of positive and negative feedback

BMC Research Notes, 2021
Objective The Hedgehog pathway is a fundamental signaling pathway in organogenesis. The expression patterns of the ligand Sonic Hedgehog (Shh) and key pathway components have been studied in many tissues but direct spatial comparisons across tissues with
Crystal L. Sigulinsky, Xiaodong Li, Edward M. Levine   +2 more
doaj   +1 more source

A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth [PDF]

, 2019
Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1)
Balducci, Silvia, BASILI, IRENE, Botta, Bruno, Bufalieri, Francesca, Caimano, Miriam, Di Marcotullio, Lucia, Ghirga, Francesca, Infante, Paola, LORICCHIO, ELENA, LOSPINOSO SEVERINI, LUDOVICA, Maroder, Marella, Moretti, Marta, Mori, Mattia, Quaglio, Deborah, ROMEO, ISABELLA   +14 more
core   +1 more source

RETRACTED: TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway

Thoracic Cancer, 2021
Background Transmembrane protein 107 (TMEM107) is a key regulator of the cilium composition and Hedgehog signaling. Lower TMEM107 gene copies are correlated with poor prognosis in non‐small cell lung carcinoma (NSCLC). However, TMEM107 protein expression,
Huihui Xu, Song Dun, Ying Gao, Jian Ming, Linping Hui, Xueshan Qiu   +5 more
doaj   +1 more source

Hedgehog signaling pathway and gastric cancer [PDF]

Cancer Biology & Therapy, 2005
Hedgehog, WNT, FGF and BMP signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. Aberrant activation of Hedgehog signaling pathway leads to pathological consequences in a variety of human tumors, such as gastric cancer and pancreatic cancer.
Yuriko, Katoh, Masaru, Katoh
openaire   +2 more sources

Characterizing hedgehog pathway features in senescence associated osteoarthritis through Integrative multi-omics and machine learning analysis

Frontiers in Genetics
Purpose: Osteoarthritis (OA) is a disease of senescence and inflammation. Hedgehog’s role in OA mechanisms is unclear. This study combines Bulk RNA-seq and scRNA-seq to identify Hedgehog-associated genes in OA, investigating their impact on the ...
Tao Wang, Zhengrui Li, Shijian Zhao, Ying Liu, Wenliang Guo, Raquel Alarcòn Rodrìguez, Yinteng Wu, Ruqiong Wei   +7 more
doaj   +1 more source

Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma [PDF]

, 2010
Background The Sonic hedgehog (Shh) signaling pathway is critical for cell growth and differentiation. Impairment of this pathway can result in both birth defects and cancer.
Afzal, Mohammad, Castresana, Javier S, Eberhart, Charles G., Fan, Xing, Rey, Juan A, Shahi, Mehdi H, Sinha, Subrata   +6 more
core   +5 more sources

The Hedgehog Signaling Pathway in Cancer [PDF]

Clinical Cancer Research, 2006
AbstractThe Hedgehog (Hh) pathway is a signaling cascade that directs patterning in most animals and is crucial for proper development. At the molecular level, Hh ligands drive cell proliferation in some cell types while causing others to undergo differentiation. Hh signaling is most active during embryogenesis, and aberrant reactivation of the pathway
Marie, Evangelista, Hua, Tian, Frederic J, de Sauvage   +2 more
openaire   +3 more sources

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. [PDF]

, 2016
Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF-κB expression in 51 breast cancer (ductal carcinoma) tissues using immunohistochemistry ...
Bei, R., Benvenuto, M, Bonanno, E, Cucchi, Danilo, DE SMAELE, Enrico, DI STEFANO, Enrica, Fantini, M, Frajese, Gv, Gulino, Alberto, Masuelli, Laura, Mattera, Rosanna, Modesti, A, Orlandi, A, Screpanti, Isabella   +13 more
core   +1 more source

Hedgehog/Gli2 signaling triggers cell proliferation and metastasis via EMT and wnt/β-catenin pathways in oral squamous cell carcinoma

Heliyon
Background: Oral squamous cell carcinoma (OSCC) is the most lethal oral malignant tumor, however, clinical outcomes remain unsatisfactory. The Hedgehog/Gli2 pathway plays a pivotal role in tumor progression, yet the regulatory mechanism governing its ...
Xiaotang Wang, Xiaona Song, Jiping Gao, Guoqiang Xu, Xiaoru Yan, Junting Yang, Yiyan Yang, Guohua Song   +7 more
doaj   +1 more source