Results 161 to 170 of about 1,857,972 (264)

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Clinical and Histological Predictors of Advanced Basal Cell Carcinoma Recurrence After Complete Response to Hedgehog Pathway Inhibitors: A Retrospective Multicenter Observational Study. [PDF]

Cancers (Basel)
Mannino M, Scalvenzi M, Di Stefani A, Costa C, Calzavara-Pinton P, Fargnoli MC, Piccerillo A, Bocchino E, Zalaudek I, Ascierto PA, Quaglino P, Queirolo P, Dika E, De Giorgi V, Moscarella E, Bianchi L, Longo C, Cantisani C, Villani A, Peris K, Collaborators.   +20 more
europepmc   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Clinical outcomes and adverse events of Hedgehog pathway inhibitors for advanced basal cell carcinoma patients: A systematic review and meta-analysis. [PDF]

Heliyon
Untaaveesup S, Dendumrongsup W, Srichana P, Pongphaew C, Techataweewan G, Viratkapan K, Nampipat N, Ponvilawan B, Kositamongkol C, Pratchyapruit W, Phisalprapa P.   +10 more
europepmc   +1 more source

Sonic Hedgehog pathway inhibitors: from clinical trials to clinical practice. [PDF]

Br J Dermatol, 2019
Yan BY, Hibler BP, Menge T, Dunn L, Ho AL, Rossi AM.   +5 more
europepmc   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2719-2737, December 2026.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies. [PDF]

Am J Clin Dermatol
Farberg AS, Portela D, Sharma D, Kheterpal M.   +3 more
europepmc   +1 more source

Integrated single‐cell transcriptomics reveals miR‐941 targets CLDN4 to inhibit malignant progression of thyroid cancer through the PI3K/AKT signaling pathway

Journal of Cell Communication and Signaling, Volume 20, Issue 4, December 2026.
The combined single‐cell and functional analysis depicts that miR‐941 targets CLDN4 and activates the regulatory axis that drives the malignancy of thyroid cancer through the PI3K/AKT pathway. Abstract Claudin‐4 (CLDN4), a key tight junction protein, has been implicated in tumor progression; however, its functional role and regulatory mechanisms in ...
Jinghua Zhou, Tiancheng Fu, Guoxiang Huang, Guangfeng Luo, Chengcheng Wang, Yanze Wang, Ziyang Ding, Xiarong Hu, Yudong Li, Zhen Li   +9 more
wiley   +1 more source

Hedgehog pathway inhibitors for locally advanced and metastatic basal cell carcinoma: A real-world single-center retrospective review. [PDF]

PLoS One
Patel S, Armbruster H, Pardo G, Archambeau B, Kim NH, Jeter J, Wu R, Kendra K, Contreras CM, Spaccarelli N, Dulmage B, Pootrakul L, Carr DR, Verschraegen C.   +13 more
europepmc   +1 more source

Bioinformatics Identification of lncRNA‐Associated Molecular Signatures Potentially Related to Quercetin Response in Breast Cancer

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Breast cancer affects approximately one in every eight women globally, as reported by the World Health Organization. Among all female malignant tumors, breast cancer has the highest fatality rate, surpassed only by lung cancer. Advanced stages of this disease are almost always fatal, and despite the advancements in surgical techniques and ...
Mahboobeh Mehrabani Natanzi, Zohreh Khodaii, Naghmeh Zhalehjoo   +2 more
wiley   +1 more source