Results 181 to 190 of about 28,708 (231)

The role of pluripotency regulators in triple-negative breast cancer immune response. [PDF]

Front Genet
López-Santana C, Mendez-Rivera F, Bernal-Estévez DA.   +2 more
europepmc   +1 more source

The nociceptor primary cilium. [PDF]

Brain
Ganter GK, Reveche HC, Fitzsimons LA, Khomula EV, Levine JD, Tucker KL.   +5 more
europepmc   +1 more source

Dual Hedgehog/GLI1 and PI3K/Akt/mTOR Targeting Possesses Higher Efficacy to Inhibit T-Cell Acute Lymphoblastic Leukemia Growth. [PDF]

Cells
De Chiara M, Sicurella M, Melloni M, Conti I, Neri LM.   +4 more
europepmc   +1 more source

Itraconazole in the Treatment of Aberrantly Active Hedgehog and/or PI3K Recurrent Ovarian Cancer. [PDF]

Cancers (Basel)
Hendrikse CSE, Voeten N, van der Ploeg P, Smedts HPM, Westgeest HM, Bosch S, Lalisang RI, Vriens BEPJ, Thijs AMJ, Lambrechts S, Bekkers RLM, Piek JMJ.   +11 more
europepmc   +1 more source

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Emerging from their burrow: Hedgehog pathway inhibitors for cancer

Expert Opinion on Investigational Drugs, 2016
Cancer treatment is moving away from conventional cytotoxic drugs and towards agents that target specific proteins and mechanisms important to cancer development or survival. The Hedgehog Pathway (HhP) is a signal transduction pathway and its constitutive activation is tumorigenic in basal cell carcinoma (BCC).
Gregory N Gan, Antonio Jimeno
exaly   +3 more sources

Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer

Archives of Pharmacal Research, 2012
Over the past decade, the Hedgehog signaling pathway has attracted considerable interest because the pathway plays important roles in the tumorigenesis of several types of cancer as well as developmental processes. It has also been observed that Hedgehog signaling regulates the proliferation and self-renewal of cancer stem cells.
Jeong In Yun, Haeil Park, Sang Kyum Kim
exaly   +3 more sources

Potent Inhibitors of the Hedgehog Signaling Pathway

Journal of Medicinal Chemistry, 2008
A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.
Shirley A, Brunton, John H A, Stibbard, Lee L, Rubin, Lawrence I, Kruse, Oivin M, Guicherit, Edward A, Boyd, Steven, Price   +6 more
openaire   +2 more sources

Clinical Experience With Hedgehog Pathway Inhibitors

Journal of Clinical Oncology, 2010
The Hedgehog (Hh) signaling pathway is critical for cell growth and differentiation during embryogenesis and early development. While it is mostly quiescent in adults, inappropriate reactivation of the Hh pathway has been shown to be involved in the development of cancer.
Jennifer A, Low, Frederic J, de Sauvage
openaire   +2 more sources