Results 181 to 190 of about 1,857,972 (264)

Mechanisms of Tumor Cell Invasion: Insights From the Perspective of Epithelial‐to‐Mesenchymal Transition

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Tumor invasion implies aberrantly increased cell motility, and is the first step of the cascade of events culminating in the development of distant metastases. The emergence of migratory capacity in epithelial carcinomas, consisting essentially of stationary cells, is linked to the activation of the epithelial‐to‐mesenchymal transition (EMT ...
Marcello Guarino
wiley   +1 more source

Doubling Down with Inhibitors of Notch and Hedgehog Signaling Pathways [PDF]

Journal of Thoracic Oncology, 2012
openaire   +2 more sources

The Potential Role of Gut Microbiome Dysbiosis and Functional Reprogramming in Colorectal Liver Metastasis via the Gut–Liver Axis

Cancer Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background Colorectal liver metastasis (CRLM) is a leading cause of mortality in colorectal cancer (CRC), yet current surveillance often misses occult micrometastases, underscoring an urgent need for early non‐invasive biomarkers and mechanistic insights.
Yuejin Sheng, Xiaoyu Dai, Jiaqi Lu, Hao Zhang, Ping Cai   +4 more
wiley   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1301-1314, November 2026.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

LncRNA A1BGAS1 Serves as a Tumor Suppressor in Non‐Small Cell Lung Cancer by Modulating the Expression of miR‐3942‐5P

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
This study verified the potential of A1BG‐AS1 to serve as a molecular biomarker for NSCLC prognosis. Mechanistically, A1BG‐AS1 exerts inhibitory effects on NSCLC cell proliferation, migration, and invasion and exerts a promoting effect on apoptosis via direct targeting and downregulation of miR‐3942‐5p.
Jiahui Du, Zhenhua Li, Chunqiang Wang, Xuexi Zhang   +3 more
wiley   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, Volume 6, Issue 11, Page 473-489, November 2026.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Tumor Size and Early Response to Sonidegib in Locally Advanced Basal Cell Carcinoma: A Real- Life Case Series

Dermatology Practical & Conceptual
Vincenzo De Giorgi, Gabriella Perillo, Giovanni Cecchi, Federica Fazzari, Biancamaria Zuccaro   +4 more
doaj   +1 more source

Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL‐KrasG12D/+; p48Cre/+ Mice

Molecular Carcinogenesis, Volume 65, Issue 11, Page 1383-1397, November 2026.
ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata, Deepanshi Dhar, Rama Kant, Robin Kumar, Md. Imtiazul Kabir, Chapla Agarwal, Rajesh Agarwal, Komal Raina   +7 more
wiley   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Liver Injury Repair and Regeneration: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 11, November 2026.
This review outlines the spatiotemporal framework of liver injury repair and regeneration, orchestrated by molecular signaling, multicellular niche crosstalk, metabolic reprogramming, and interorgan communication. Post‑injury regenerative cascades (initiation, proliferation, termination) rely on crosstalk between hepatocytes, Kupffer cells, hepatic ...
Mingyue Pan, Ni An, Yutian Feng, Yuelei Hu, Chongqin Pan, Yuxin Su, Yuanzheng Huang, Tanqing Long, Qi Wang, Qingru Song, Pengfei Li, Xiaomeng Li, Wenzhen Yin, Zhiyuan Hu, Xiaoxuan Liu, Juan Liu   +15 more
wiley   +1 more source