MedComm – Oncology, Volume 5, Issue 4, December 2026.β‐arrestin1 promotes prostate cancer progression by suppressing epithelial splicing regulatory protein 1 (ESRP1) expression and shifting CD44 alternative splicing toward CD44s and away from CD44v2 and CD44v6. These changes accompany increased N‐cadherin, decreased E‐cadherin, and enhanced epithelial–mesenchymal transition.
Sicheng Dong +12 more
wiley +1 more source
A Practical Guide for the Follow-Up of Patients with Advanced Basal Cell Carcinoma During Treatment with Hedgehog Pathway Inhibitors. [PDF]
Oncologist, 2019 Dessinioti C +6 more
europepmc +1 more source
Depicting the Immunological Landscape of Basal Cell Carcinoma Subtypes
Journal of Cutaneous Pathology, Volume 53, Issue 12, Page 1131-1141, December 2026.ABSTRACT Background Anti‐PD‐1 response has been associated with higher PD‐1 ligand (PD‐L1) expression levels in different cancer types. Cemiplimab, an anti‐PD‐1 antibody, has been shown to induce a response rate of 31% and 22% in patients with locally advanced basal cell carcinoma (BCC) and metastatic BCC respectively, who have progressed or are ...
Isabella Dommann +9 more
wiley +1 more source
Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors. [PDF]
J Med Chem, 2019 Pace JR +6 more
europepmc +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan +3 more
wiley +1 more source
Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence. [PDF]
Dermatol Ther (Heidelb), 2019 Tay EY, Teoh YL, Yeo MS.
europepmc +1 more source
Organoids in pediatric cancer research
FEBS Letters, Volume 600, Issue 21, Page 3221-3240, November 2026.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer. [PDF]
Open Biol, 2018 Curran T.
europepmc +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, Volume 38, Issue 61, 2 November 2026.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis
Arthritis &Rheumatology, Volume 78, Issue 11, Page 2189-2202, November 2026.Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo +7 more
wiley +1 more source