Results 191 to 200 of about 1,857,972 (264)

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

MCP‐1 From Aging Dermal Adipose Tissue Impairs Hair Follicle Cycling via Macrophage Recruitment: Implications for Age‐Related Alopecia

Aging Cell, Volume 25, Issue 11, November 2026.
Aging orchestrates a dWAT–MCP‐1–CCR2 axis that recruits and reprograms macrophage subpopulations, disrupting the local M1/M2 balance and suppressing WNT signaling, thereby impairing both hair cycle transition and production of genes associated with melanogenesis.
Jian Chen, Yuhui Hou, Ke Ye, Yilong Guo, Pingping Sun, Fangfang Qi, Zhexiang Fan, Damao Dai, Xiaomin Liu, Shulian Wu, Demengjie Le, Zhiqi Hu, Yong Miao, Qian Qu   +13 more
wiley   +1 more source

Dysglycaemia and Autonomic Dysfunction: The Diabetes Prevention Program Outcomes Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10743-10752, November 2026.
ABSTRACT Aim Limited data on the link between various measures of glycemia and metabolism and autonomic dysfunction exist. We assessed the association of fasting plasma glucose [FPG], glycated haemoglobin [HbA1C], fasting insulin, and HOMA‐IR and cardiac autonomic function measures separately for men and women in the Diabetes Prevention Program ...
Justin B. Echouffo‐Tcheugui, Xun Liu, Elsayed Z. Soliman, Xavier Pi‐Sunyer, Sherita H. Golden, Sam Dagogo‐Jack, Neil H. White, Matthew Budoff, Uzoma Ibebuogu, Christine Darwin, William C. Knowler, Marinella Temprosa, on behalf of the DPP Research Group   +12 more
wiley   +1 more source

PIH1D2 Loss‐of‐Function Directs Ciliary and Cell Cycle Defects Resulting in Left Isomerism With or Without Biliary Atresia

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background & Aims Laterality disorders are rare congenital conditions caused by disruption of left–right embryonic patterning, often associated with ciliary dysfunction. Despite the identification of numerous causative genes, the molecular basis remains unresolved in many patients.
Alina Kurolap, Chofit Chai Gadot, Adel Shalata, Orly Eshach Adiv, Yam Amir, Bar Levy Lando, Florian Stehling, Tova Hershkovitz, Khaled Osman, Clair Habib, Hila Mintz, Ran Steinberg, Amit Hochberg, Uri Hamiel, Adi Mory, Daphna Marom, Sandra von Hardenberg, Amihood Singer, Bernd Auber, Hagit Baris Feldman   +19 more
wiley   +1 more source

Giant Keratinocyte Carcinomas: Clinical, Histopathological, Molecular and Health-System Factors with Therapeutic Implications-A Structured Narrative Review. [PDF]

Cancers (Basel)
Ciborek A, Krauss H, Chęcińska-Maciejewska Z, Jaworek AK.   +3 more
europepmc   +1 more source

Contemporary Multimodal Management of Cutaneous Malignancies: Surgery, Radiotherapy, Systemic Therapy, Molecular Targeting and Immunotherapy. [PDF]

Cancers (Basel)
Kowalczyk D, Jaworek J, Ciborek A, Kolodziejski PA, Pruszyńska-Oszmałek E, Krauss H.   +5 more
europepmc   +1 more source

Cell differentiation-related signaling pathways: biological functions, diseases and therapeutic targets. [PDF]

Signal Transduct Target Ther
Xiang Z, Li J, Xu Y, Xu C, Li S, Zheng S, Yang Z, Wei X, Xu X.   +8 more
europepmc   +1 more source

The Role of METTL3-Mediated m⁶A Methylation in Hepatocellular Carcinoma Progression and Treatment. [PDF]

Epigenomes
Maduranga BGNH, Yang HD, Lee SI, Eun JW, Lim SY, Kim HS, Jeong JY.   +6 more
europepmc   +1 more source

Signaling pathway mechanisms in pancreatic ductal adenocarcinoma tumor microenvironment and emerging targeting strategies for improved prognosis. [PDF]

Oncol Rev
Akinsipe T, Odewumi CO, Latinwo L, Aghimien OO, Musa MA, Igbinoba PO, Simons AL, Aghimien MO.   +7 more
europepmc   +1 more source