Results 201 to 210 of about 28,708 (231)
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Sonic hedgehog pathway inhibitor mitigates mouse hepatocellular carcinoma
The American Journal of Surgery, 2015Hepatocellular carcinoma (HCC) is a leading cause of death in Asian countries. Sonic hedgehog (Shh) pathway plays a role in hepatocarcinogenesis. We investigated the treatment effect of mouse HCC with Shh inhibitor GDC-0449.Mouse hepatoma ML-1 cells were implanted in B6 mice. Fifteen days later, GDC-0449 (vismodegib), antagonist of smoothened, was used
Kuo-Shyang Jeng +8 more
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Embryofetal Development Study of Vismodegib, a Hedgehog Pathway Inhibitor, in Rats
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2014Vismodegib (Erivedge) is a first‐in‐class small‐molecule hedgehog pathway inhibitor for the treatment of adults with advanced basal‐cell carcinoma. Because this pathway is known to play key roles in patterning and growth during vertebrate development, vismodegib was anticipated to be embryotoxic.
Eric, Morinello +4 more
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Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies
Expert Opinion on Drug Discovery, 2014The Hedgehog (Hh) signaling pathway is known to be dysregulated in several forms of cancer. Hence, specifically targeting this signaling cascade is a valid and promising strategy for successful therapeutic intervention. Several components within the Hh pathway have been proven to be druggable; however, challenges in the discovery and development ...
Upasana, Banerjee, Matthew Kyle, Hadden
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Inhibitors of the Hedgehog Signal Transduction Pathway
Current Cancer Therapy Reviews, 2005David Robbins +3 more
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Hedgehog pathway inhibitors come of age
British Journal of Dermatology, 2019openaire +2 more sources
Hedgehog Pathway Inhibitors for Periocular Basal Cell Carcinoma
International Ophthalmology Clinics, 2020Davin C, Ashraf, M Reza, Vagefi
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Multitarget hedgehog pathway inhibitors and uses thereof
2014The present invention concerns compds. that selectively inhibit the activity of the Hedgehog (Hh) pathway, their prepn. and uses thereof. The compds. of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).
BOTTA, Bruno +9 more
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The Hedgehog pathway and its inhibitors: Emerging therapeutic approaches for basal cell carcinoma
Drug Discovery Today, 2022Rupesh Jain +2 more
exaly
Development of taladegib as a sonic hedgehog signaling pathway inhibitor
Archives of Pharmacal Research, 2017Guanghai Jin +2 more
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