Results 31 to 40 of about 1,857,972 (264)
Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer
Cells, 2019 The Hedgehog/GLI signaling pathway plays an important role in normal embryonic tissue development and has been implicated in the pathogenesis of various human cancers.
Hao Xie +3 more
doaj +1 more source
Sonidegib en el tratamiento del carcinoma basocelular localmente avanzado
Actas Dermo-Sifiliográficas, 2021 Resumen: Sonidegib es un inhibidor del receptor transmembrana Smoothened (SMO), de la vía de señalización de Hedgehog, indicado para el tratamiento del carcinoma basocelular localmente avanzado (CBCla), no susceptible a cirugía curativa ni a radioterapia.
O. Sanmartín +6 more
doaj +1 more source
, 2016 Smoothened is a critical component of the Hedgehog pathway that is essential for stem cell renewal and is dysregulated in many cancer types. We have found synthetic analogues of the second and third intracellular loops of smoothened to be potent ...
Hong Lou (2477365) +4 more
core +2 more sources
SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. [PDF]
PLoS ONE, 2015 Although there is much evidence showing functional relationship between Hedgehog pathway, in particular Sonic hedgehog, and SOX transcription factors during embryonic development, scarce data are available regarding their crosstalk in cancer cells. SOX18
Isidora Petrovic +5 more
doaj +1 more source
Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents [PDF]
Journal of Medicinal Chemistry, 2009 Cancer drug discovery has undergone a paradigm change over the past few years, from predominantly cytotoxic agent-based therapy to therapy aimed at genetic and molecular targets, thanks to a growing understanding of the genes and pathways responsible for cancer initiation and progression and to new drug discovery technologies. The success of drugs like
Neeraj, Mahindroo +2 more
openaire +2 more sources
NOVEL APPROACH TO THE HEDGEHOG SIGNALING PATHWAY: COMBINED TREATMENT OF SMO AND PTCH INHIBITORS
, 2023 Purpose: Abnormal Sonic Hedgehog signaling Pathway (Shh) activation is crucial for the development of cancer stem cells, neoplastic growth, and epithelial-mesenchymal transition processes in adulthood.
Yasemin BAŞBINAR +3 more
core +1 more source
Efficacy of Hedgehog Pathway Inhibitors in Basal Cell Carcinoma [PDF]
Molecular Cancer Therapeutics, 2015 Abstract Basal cell carcinoma (BCC) is the most commonly diagnosed cancer. While most BCCs are amenable to surgery, some tumors can reach a more advanced stage or metastasize, and become ineligible for surgical resection or radiotherapy. Abnormal activation of the Hedgehog (Hh) pathway is a key driver in BCC pathophysiology. Consequently,
Nicole, Basset-Seguin +2 more
openaire +2 more sources
Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling. [PDF]
PLoS Genetics, 2016 For homeostasis, lingual taste papilla organs require regulation of epithelial cell survival and renewal, with sustained innervation and stromal interactions.
Alexandre N Ermilov +7 more
doaj +1 more source
Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source
Analysis of Sonic Hedgehog signalling pathway gene expression in Basal Cell Carcinoma and in GLII induced systems [PDF]
, 2007 PhDEmbryonic development is regulated by a number of signalling pathways, Which are critical for normal growth. Many of these genes then continue to play an important role in the regulation of cell growth and differentiation in adult.
Ikram, Mohammed S, Ikram, Mohammed. S.
core +2 more sources