Results 11 to 20 of about 28,708 (231)

Endocannabinoids are conserved inhibitors of the Hedgehog pathway [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Hedgehog proteins regulate development and tissue homeostasis. They signal through activation of the transmembrane protein Smoothened. Smoothened hyperactivation underlies development of many tumors. Smoothened activity can be modulated by several synthetic small molecules, which have shown promise in the clinic.
Khaliullina, H., Bilgin, M., Sampaio, J., Shevchenko, A., Eaton, S.   +4 more
openaire   +3 more sources

Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1

Nature Communications, 2023
Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Many screens have been conducted to find inhibitors for the Hedgehog signaling pathway – a developmental pathway with many implications in health and disease –
Meropi Bagka, Hyeonyi Choi, Margaux Héritier, Hanna Schwaemmle, Quentin T. L. Pasquer, Simon M. G. Braun, Leonardo Scapozza, Yibo Wu, Sascha Hoogendoorn   +8 more
doaj   +1 more source

Antiosteogenic effect of arsenic trioxide, cholecalciferol, lovastatin or their combination in vitro [PDF]

Journal of the Serbian Chemical Society, 2019
Pathological formation of bone in non-skeletal soft tissues or heterotopic ossification (HO), for which there is currently no effective treatment, is considered to be mediated by activation of Hedgehog (Hh) signaling pathway.
Gvozdenović-Jeremić Jelena, Vert-Wong Ekaterina, Mojović Ljiljana   +2 more
doaj   +1 more source

Discovery of Small Molecule Inhibitors Targeting the Sonic Hedgehog

Frontiers in Chemistry, 2020
The aberrant activation of hedgehog (Hh) signaling pathway is closely related to human diseases. The upstream protein, N-terminal product of sonic hedgehog (ShhN) is overexpressed in many cancers and considered as a promising antitumor target. Inhibitors
Taikangxiang Yun, Juan Wang, Jun Yang, Wenjing Huang, Luhua Lai, Wenfu Tan, Ying Liu   +6 more
doaj   +1 more source

Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas

BMC Veterinary Research, 2023
Background The hedgehog signalling pathway has been implicated in tumourigenesis and progression of many tumour types. This pathway has recently emerged as a therapeutic target, and inhibitors of hedgehog signalling have gained considerable attention. In
Haein Koo, Sungin Lee, Wan Hee Kim
doaj   +1 more source

Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents [PDF]

Journal of Medicinal Chemistry, 2009
Cancer drug discovery has undergone a paradigm change over the past few years, from predominantly cytotoxic agent-based therapy to therapy aimed at genetic and molecular targets, thanks to a growing understanding of the genes and pathways responsible for cancer initiation and progression and to new drug discovery technologies. The success of drugs like
Neeraj, Mahindroo, Chandanamali, Punchihewa, Naoaki, Fujii   +2 more
openaire   +2 more sources

Activation of hedgehog signaling is not a frequent event in ovarian cancers

Molecular Cancer, 2009
The hedgehog (Hh) signaling pathway regulates many processes of development and tissue homeostasis. Activation of hedgehog signaling has been reported in about 30% of human cancer including ovarian cancer.
Zhang Xiaoli, Huang Shuhong, He Jing, Yang Ling, Bian Yuehong, He Nonggao, Zhang Hongwei, Xie Jingwu   +7 more
doaj   +1 more source

Update on Hedgehog Pathway Inhibitor Therapy for Patients with Basal Cell Naevus Syndrome or High-frequency Basal Cell Carcinoma

Acta Dermato-Venereologica, 2022
Some patients with basal cell carcinoma develop a large number of basal cell carcinomas during their lives. The most common underlying genetic disease that causes multiple basal cell carcinomas is basal cell naevus syndrome. Basal cell naevus syndrome is
Babette J.A. Verkouteren, Kelly A.E. Sinx, Marie G.H.C. Reinders, Maureen J.B. Aarts, Klara Mosterd   +4 more
doaj   +1 more source

Efficacy of Hedgehog Pathway Inhibitors in Basal Cell Carcinoma [PDF]

Molecular Cancer Therapeutics, 2015
Abstract Basal cell carcinoma (BCC) is the most commonly diagnosed cancer. While most BCCs are amenable to surgery, some tumors can reach a more advanced stage or metastasize, and become ineligible for surgical resection or radiotherapy. Abnormal activation of the Hedgehog (Hh) pathway is a key driver in BCC pathophysiology. Consequently,
Nicole, Basset-Seguin, Hayley J, Sharpe, Frederic J, de Sauvage   +2 more
openaire   +2 more sources

Identification of a potent antagonist of smoothened in hedgehog signaling

Cell & Bioscience, 2021
Background Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics.
Junwan Fan, Haowen Li, Lun Kuang, Zichen Zhao, Wenyan He, Chen Liu, Yongjun Wang, Steven Y. Cheng, Wei Chen   +8 more
doaj   +1 more source