Results 11 to 20 of about 1,857,972 (264)
Hedgehog pathway inhibitors – current status and future prospects [PDF]
Infectious Agents and Cancer, 2012 The Hedgehog (Hh) proteins comprise a group of secreted proteins that regulate cell growth, differentiation and survival. Inappropriate activation of the Hh signaling pathway has been implicated in the development of a variety of cancers.
Sheikh Asfandyar +3 more
doaj +4 more sources
Safety and Tolerability of Sonic Hedgehog Pathway Inhibitors in Cancer. [PDF]
Drug Saf, 2019 The hedgehog pathway, for which sonic hedgehog (Shh) is the most prominent ligand, is highly conserved and is tightly associated with embryonic development in a number of species.
Carpenter RL, Ray H.
europepmc +5 more sources
Clinical implications of hedgehog signaling pathway inhibitors
Chinese Journal of Cancer, 2011 Hedgehog was first described in Drosophila melanogaster by the Nobel laureates Eric Wieschaus and Christiane Nüsslein-Volhard. The hedgehog (Hh) pathway is a major regulator of cell differentiation, proliferation, tissue polarity, stem cell maintenance ...
Hailan Liu +5 more
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Clinical Experience With Hedgehog Pathway Inhibitors
Journal of Clinical Oncology, 2010 The Hedgehog (Hh) signaling pathway is critical for cell growth and differentiation during embryogenesis and early development. While it is mostly quiescent in adults, inappropriate reactivation of the Hh pathway has been shown to be involved in the ...
Jennifer A. Low, Frederic J. de Sauvage
core +3 more sources
Integrated QSAR study for inhibitors of hedgehog signal pathway against multiple cell lines:a collaborative filtering method [PDF]
BMC Bioinformatics, 2012 Background The Hedgehog Signaling Pathway is one of signaling pathways that are very important to embryonic development. The participation of inhibitors in the Hedgehog Signal Pathway can control cell growth and death, and searching novel inhibitors to ...
Gao Jun +4 more
doaj +2 more sources
A highlight on Sonic hedgehog pathway
Cell Communication and Signaling, 2018 Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio and chemo-resistance of several types of ...
Gabriela Basile Carballo +3 more
doaj +2 more sources
Targeting Hedgehog (Hh) Pathway for the Acute Myeloid Leukemia Treatment
Cells, 2019 The Hedgehog (Hh) pathway, containing the Patched (PTCH) and Smoothened (SMO) multitransmembrane proteins, is the main regulator of vertebrate embryonic development.
Toshiki Terao, Yosuke Minami
doaj +2 more sources
Treatment of Advanced Basal Cell Carcinoma with Hedgehog Pathway Inhibitors: A Multidisciplinary Expert Meeting. [PDF]
Cancers (Basel), 2021 Despite recent progress and the publishing of several clinical guidelines on the management of advanced basal cell carcinoma, there is still no comprehensive set of clinical guidelines addressing the complexity inherent to the use of Hedgehog pathway ...
De Giorgi V +10 more
europepmc +3 more sources
Multitarget hedgehog pathway inhibitors and uses thereof
, 2014 The present invention concerns compds. that selectively inhibit the activity of the Hedgehog (Hh) pathway, their prepn. and uses thereof. The compds. of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB)
Mori, Mattia +9 more
core +5 more sources
Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors. [PDF]
Chemistry, 2021 AbstractWithanolides constitute a well‐known family of plant‐based alkaloids characterised by widespread biological properties, including the ability of interfering with Hedgehog (Hh) signalling pathway. Following our interest in natural products and in anticancer compounds, we report here the synthesis of a new class of Hh signalling pathway ...
Bonandi E +8 more
europepmc +5 more sources