Results 1 to 10 of about 29,748 (116)
Hedgehog Pathway Inhibitors against Tumor Microenvironment [PDF]
Cells, 2021 Targeting the hedgehog (HH) pathway to treat aggressive cancers of the brain, breast, pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been long discovered within malignant glioma patients, and since then, inhibitors ...
Silpa Gampala, Jer-Yen Yang
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Treatment of periocular advanced basal cell carcinoma with Hedgehog pathway inhibitors: a single-center study and a new dedicated therapeutic protocol [PDF]
Dermatology Reports, 2021 Background: The management of difficult-to-treat periocular basal cell carcinoma becomes very challenging in cases of delayed diagnosis, leading to the development of locally advanced basal cell carcinoma. Objective: The aim of this study was to evaluate
Vincenzo De Giorgi +13 more
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Evaluation of Benzo[cd]indol‐2(1H)‐ones as Downstream Hedgehog Pathway Inhibitors [PDF]
ChemistryOpenEpigenetic targeting of the Hedgehog (HH) signaling pathway has emerged as a possible strategy to combat HH pathway‐driven cancers. In this study, we report on benzo[cd]indol‐2(1H)‐ones as downstream Hedgehog pathway inhibitors.
Dr. Ioannis A. Tsakoumagkos +8 more
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Combined cemiplimab and radiotherapy for advanced basal cell carcinoma: A case report
SAGE Open Medical Case Reports, 2023 Advanced basal cell carcinoma may be treated with systemic therapies such as hedgehog pathway inhibitors or programmed cell death protein 1 inhibitors, namely cemiplimab.
Sidra Sarfaraz +2 more
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Nature Communications, 2023 Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Many screens have been conducted to find inhibitors for the Hedgehog signaling pathway – a developmental pathway with many implications in health and disease –
Meropi Bagka +8 more
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Antiosteogenic effect of arsenic trioxide, cholecalciferol, lovastatin or their combination in vitro [PDF]
Journal of the Serbian Chemical Society, 2019 Pathological formation of bone in non-skeletal soft tissues or heterotopic ossification (HO), for which there is currently no effective treatment, is considered to be mediated by activation of Hedgehog (Hh) signaling pathway.
Gvozdenović-Jeremić Jelena +2 more
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Discovery of Small Molecule Inhibitors Targeting the Sonic Hedgehog
Frontiers in Chemistry, 2020 The aberrant activation of hedgehog (Hh) signaling pathway is closely related to human diseases. The upstream protein, N-terminal product of sonic hedgehog (ShhN) is overexpressed in many cancers and considered as a promising antitumor target. Inhibitors
Taikangxiang Yun +6 more
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Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas
BMC Veterinary Research, 2023 Background The hedgehog signalling pathway has been implicated in tumourigenesis and progression of many tumour types. This pathway has recently emerged as a therapeutic target, and inhibitors of hedgehog signalling have gained considerable attention. In
Haein Koo, Sungin Lee, Wan Hee Kim
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Activation of hedgehog signaling is not a frequent event in ovarian cancers
Molecular Cancer, 2009 The hedgehog (Hh) signaling pathway regulates many processes of development and tissue homeostasis. Activation of hedgehog signaling has been reported in about 30% of human cancer including ovarian cancer.
Zhang Xiaoli +7 more
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Acta Dermato-Venereologica, 2022 Some patients with basal cell carcinoma develop a large number of basal cell carcinomas during their lives. The most common underlying genetic disease that causes multiple basal cell carcinomas is basal cell naevus syndrome. Basal cell naevus syndrome is
Babette J.A. Verkouteren +4 more
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