Hedgehog Pathway Inhibitors against Tumor Microenvironment [PDF]
Cells, 2021 Targeting the hedgehog (HH) pathway to treat aggressive cancers of the brain, breast, pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been long discovered within malignant glioma patients, and since then, inhibitors ...
Silpa Gampala, Jer-Yen Yang
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Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors [PDF]
Chemistry - A European Journal, 2021 AbstractWithanolides constitute a well‐known family of plant‐based alkaloids characterised by widespread biological properties, including the ability of interfering with Hedgehog (Hh) signalling pathway. Following our interest in natural products and in anticancer compounds, we report here the synthesis of a new class of Hh signalling pathway ...
Mattia Mori +2 more
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Hedgehog pathway inhibitors – current status and future prospects [PDF]
Infectious Agents and Cancer, 2012 The Hedgehog (Hh) proteins comprise a group of secreted proteins that regulate cell growth, differentiation and survival. Inappropriate activation of the Hh signaling pathway has been implicated in the development of a variety of cancers.
Sheikh Asfandyar +3 more
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Treatment of periocular advanced basal cell carcinoma with Hedgehog pathway inhibitors: a single-center study and a new dedicated therapeutic protocol [PDF]
Dermatology Reports, 2021 Background: The management of difficult-to-treat periocular basal cell carcinoma becomes very challenging in cases of delayed diagnosis, leading to the development of locally advanced basal cell carcinoma. Objective: The aim of this study was to evaluate
Vincenzo De Giorgi +13 more
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Design of Hedgehog pathway inhibitors for cancer treatment. [PDF]
Med Res Rev, 2019 AbstractHedgehog (Hh) signaling is involved in the initiation and progression of various cancers and is essential for embryonic and postnatal development. This pathway remains in the quiescent state in adult tissues but gets activated upon inflammation and injuries.
Bariwal J, Kumar V, Dong Y, Mahato RI.
europepmc +4 more sources
Safety and Tolerability of Sonic Hedgehog Pathway Inhibitors in Cancer. [PDF]
Drug Saf, 2019 The hedgehog pathway, for which sonic hedgehog (Shh) is the most prominent ligand, is highly conserved and is tightly associated with embryonic development in a number of species. This pathway is also tightly associated with the development of several types of cancer, including basal cell carcinoma (BCC) and acute promyelocytic leukemia, among many ...
Carpenter RL, Ray H.
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Evaluation of Benzo[cd]indol‐2(1H)‐ones as Downstream Hedgehog Pathway Inhibitors [PDF]
ChemistryOpenEpigenetic targeting of the Hedgehog (HH) signaling pathway has emerged as a possible strategy to combat HH pathway‐driven cancers. In this study, we report on benzo[cd]indol‐2(1H)‐ones as downstream Hedgehog pathway inhibitors.
Dr. Ioannis A. Tsakoumagkos +8 more
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Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors [PDF]
Beilstein Journal of Organic Chemistry, 2012 Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity ...
Chao Che +8 more
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Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma. [PDF]
Clin Cancer Res, 2018 Abstract Purpose: The role of cholesterol biosynthesis in hedgehog pathway activity and progression of hedgehog pathway medulloblastoma (Hh-MB) were examined in vivo. Statins, commonly used cholesterol-lowering agents, were utilized to validate cholesterol biosynthesis as a therapeutic target for Hh-MB.
Gordon RE +10 more
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Combined cemiplimab and radiotherapy for advanced basal cell carcinoma: A case report
SAGE Open Medical Case Reports, 2023 Advanced basal cell carcinoma may be treated with systemic therapies such as hedgehog pathway inhibitors or programmed cell death protein 1 inhibitors, namely cemiplimab.
Sidra Sarfaraz +2 more
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