Results 21 to 30 of about 28,708 (231)

Clinical implications of hedgehog signaling pathway inhibitors

Chinese Journal of Cancer, 2011
Hedgehog was first described in Drosophila melanogaster by the Nobel laureates Eric Wieschaus and Christiane Nüsslein-Volhard. The hedgehog (Hh) pathway is a major regulator of cell differentiation, proliferation, tissue polarity, stem cell maintenance, and carcinogenesis.
Liu, Hailan, Gu, Dongsheng, Xie, Jingwu
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Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß [PDF]

Angewandte Chemie International Edition, 2019
AbstractThe Hedgehog (Hh) signaling pathway is crucial for vertebrate embryonic development, tissue homeostasis and regeneration. Hh signaling is upregulated in basal cell carcinoma and medulloblastoma and Hh pathway inhibitors targeting the Smoothened (SMO) protein are in clinical use.
Lea Kremer, Elisabeth Hennes, Alexandra Brause, Andrei Ursu, Lucas Robke, Hideaki T. Matsubayashi, Yuta Nihongaki, Jana Flegel, Ivana Mejdrová, Jan Eickhoff, Matthias Baumann, Radim Nencka, Petra Janning, Susanne Kordes, Hans R. Schöler, Jared Sterneckert, Takanari Inoue, Slava Ziegler, Herbert Waldmann   +18 more
openaire   +5 more sources

Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling

Cancer Cell International, 2008
Background Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation.
Prowse David M, Shaw Greg
doaj   +1 more source

Sonidegib en el tratamiento del carcinoma basocelular localmente avanzado

Actas Dermo-Sifiliográficas, 2021
Resumen: Sonidegib es un inhibidor del receptor transmembrana Smoothened (SMO), de la vía de señalización de Hedgehog, indicado para el tratamiento del carcinoma basocelular localmente avanzado (CBCla), no susceptible a cirugía curativa ni a radioterapia.
O. Sanmartín, B. Llombart, G. Carretero Hernández, Á. Flórez Menéndez, R. Botella-Estrada, E. Herrera Ceballos, S. Puig   +6 more
doaj   +1 more source

Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer

Cells, 2019
The Hedgehog/GLI signaling pathway plays an important role in normal embryonic tissue development and has been implicated in the pathogenesis of various human cancers.
Hao Xie, Brooke D. Paradise, Wen Wee Ma, Martin E. Fernandez-Zapico   +3 more
doaj   +1 more source

SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. [PDF]

PLoS ONE, 2015
Although there is much evidence showing functional relationship between Hedgehog pathway, in particular Sonic hedgehog, and SOX transcription factors during embryonic development, scarce data are available regarding their crosstalk in cancer cells. SOX18
Isidora Petrovic, Milena Milivojevic, Jelena Popovic, Marija Schwirtlich, Branislava Rankovic, Milena Stevanovic   +5 more
doaj   +1 more source

Integrated QSAR study for inhibitors of hedgehog signal pathway against multiple cell lines:a collaborative filtering method

BMC Bioinformatics, 2012
Background The Hedgehog Signaling Pathway is one of signaling pathways that are very important to embryonic development. The participation of inhibitors in the Hedgehog Signal Pathway can control cell growth and death, and searching novel inhibitors to ...
Gao Jun, Che Dongsheng, Zheng Vincent W, Zhu Ruixin, Liu Qi   +4 more
doaj   +1 more source

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449 [PDF]

New England Journal of Medicine, 2009
Medulloblastoma is the most common malignant brain tumor in children. Aberrant activation of the hedgehog signaling pathway is strongly implicated in the development of some cases of medulloblastoma. A 26-year-old man with metastatic medulloblastoma that was refractory to multiple therapies was treated with a novel hedgehog pathway inhibitor, GDC-0449;
Charles M, Rudin, Christine L, Hann, John, Laterra, Robert L, Yauch, Christopher A, Callahan, Ling, Fu, Thomas, Holcomb, Jeremy, Stinson, Stephen E, Gould, Barbara, Coleman, Patricia M, LoRusso, Daniel D, Von Hoff, Frederic J, de Sauvage, Jennifer A, Low   +13 more
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Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling. [PDF]

PLoS Genetics, 2016
For homeostasis, lingual taste papilla organs require regulation of epithelial cell survival and renewal, with sustained innervation and stromal interactions.
Alexandre N Ermilov, Archana Kumari, Libo Li, Ariell M Joiner, Marina A Grachtchouk, Benjamin L Allen, Andrzej A Dlugosz, Charlotte M Mistretta   +7 more
doaj   +1 more source

Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis. [PDF]

PLoS ONE, 2013
Hedgehog signaling pathway activation has been implicated in the pathogenesis of NASH. Despite this concept, hedgehog pathway inhibitors have not been explored. Thus, we examined the effect of vismodegib, a hedgehog signaling pathway inhibitor, in a diet-
Petra Hirsova, Samar H Ibrahim, Steven F Bronk, Hideo Yagita, Gregory J Gores   +4 more
doaj   +1 more source