Results 21 to 30 of about 1,857,972 (264)
Design of Hedgehog pathway inhibitors for cancer treatment. [PDF]
Med Res Rev, 2019 AbstractHedgehog (Hh) signaling is involved in the initiation and progression of various cancers and is essential for embryonic and postnatal development. This pathway remains in the quiescent state in adult tissues but gets activated upon inflammation and injuries.
Bariwal J, Kumar V, Dong Y, Mahato RI.
europepmc +4 more sources
The role of Sulf1 during Sonic hedgehog mediated neural patterning [PDF]
, 2011 Heparan sulphate proteoglycans (HSPGs) are large molecules distributed ubiquitously, both at the cell surface and within the extracellular matrix. These molecules are known to play essential roles in developmental cell signalling, and the differential ...
Ramsbottom, Simon.A
core +5 more sources
Hedgehog Pathway Inhibitors: A New Therapeutic Class for the Treatment of Acute Myeloid Leukemia. [PDF]
Blood Cancer Discov, 2020 Targeting Hedgehog (Hh) pathway components, such as Smoothened (SMO), is a developing strategy for the treatment of acute myeloid leukemia (AML) and for overcoming relapsed/refractory forms of this disease.
Jamieson C +3 more
europepmc +2 more sources
Endocannabinoids are conserved inhibitors of the Hedgehog pathway [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance Hedgehog proteins regulate development and tissue homeostasis. They signal through activation of the transmembrane protein Smoothened. Smoothened hyperactivation underlies development of many tumors. Smoothened activity can be modulated by several synthetic small molecules, which have shown promise in the clinic. However,
Khaliullina, H. +4 more
openaire +3 more sources
The hedgehog pathway inhibitor GDC-0449 shows potential in skin and other cancers [PDF]
, 2010 Background: The hedgehog signaling pathway is vital in early development, but then becomes dormant, except in some cancer tumours. Hedgehog inhibitors are being developed for potential use in cancer. Objectives/Methods: The objective of this evaluation
Doggrell, Sheila Anne, Sheila A Doggrell
core +1 more source
Hedgehog pathway inhibition and the race against tumor evolution [PDF]
, 2012 Dependence of basal cell carcinomas and medulloblastomas on the Hedgehog pathway provides an opportunity for targeted or "personalized" therapy. The recent effectiveness and FDA approval of the first Smoothened inhibitors validates this class of agents ...
Scott X. Atwood +5 more
core +1 more source
Identification of a potent antagonist of smoothened in hedgehog signaling
Cell & Bioscience, 2021 Background Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics.
Junwan Fan +8 more
doaj +1 more source
Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma. [PDF]
Clin Cancer Res, 2018 Abstract Purpose: The role of cholesterol biosynthesis in hedgehog pathway activity and progression of hedgehog pathway medulloblastoma (Hh-MB) were examined in vivo. Statins, commonly used cholesterol-lowering agents, were utilized to validate cholesterol biosynthesis as a therapeutic target for Hh-MB.
Gordon RE +10 more
europepmc +4 more sources
Cancer Cell International, 2008 Background Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation.
Prowse David M, Shaw Greg
doaj +1 more source
Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors
Beilstein Journal of Organic Chemistry, 2012 Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity ...
Chao Che +8 more
doaj +1 more source