, 2010 Motivation: Signaling pathways control a large variety of cellular processes. However, currently, even within the same database signaling pathways are often curated at different levels of detail.
Amberger +65 more
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Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus [PDF]
, 1999 Ge Wang, Boyuan Wang, Jin Jiang
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Gli proteins and Hedgehog signaling: development and cancer
Trends in Genetics, 1999 A surprising number of apparently unrelated human diseases, including familial and sporadic cancers and a number of syndromes and malformations, seem to be associated with abnormal function of the Hedgehog (Hh) signaling pathway. Zinc-finger transcription factors of the Gli family play critical roles in the mediation and interpretation of Hh signals ...
openaire +3 more sources
Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif [PDF]
, 2008 Thomas R. Bürglin
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Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release [PDF]
, 2021 Yitian Luo +8 more
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Microparticles harboring Sonic Hedgehog promote angiogenesis through the upregulation of adhesion proteins and proangiogenic factors [PDF]
, 2009 Raffaella Soleti +5 more
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Nanomolar, noncovalent antagonism of hedgehog cholesterolysis: exception to the “irreversibility rule” for protein autoprocessing inhibition [PDF]
, 2021 Andrew G. Wagner +8 more
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Ecotoxicology and Environmental SafetyArsenic exposure by drinking water is a key challenge in the field of public health worldwide. Research has found a connection between arsenic exposure and renal fibrosis, yet the mechanisms behind this are still unclear. In this study, rats were exposed
Pinya Liu +5 more
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The BET Bromodomain Inhibitor I-BET151 Acts Downstream of Smoothened Protein to Abrogate the Growth of Hedgehog Protein-driven Cancers [PDF]
, 2014 Jun Long +10 more
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