Results 131 to 140 of about 1,401 (218)

Cross‐Analysis of Single‐Cell Transcriptomic Datasets Reveals Conserved Neurogenic Gene Signatures and New Insights Into Neural Stem Cell Aging

Aging Cell, EarlyView.
Here, we reanalyze single‐cell RNA sequencing datasets demonstrating hippocampal adult neural stem cell (NSC) heterogeneity to resolve classification inconsistencies and identify conserved gene markers. Our findings enhance understanding of NSC dynamics, aging, and senescence, providing a framework for standardized classification and improved insights ...
Oliver Polzer, E. Kinloch, P. J. Lucassen, E. Salta, C. P. Fitzsimons   +4 more
wiley   +1 more source

Quercetin Reduces Vascular Senescence and Inflammation in Symptomatic Male but Not Female Coronary Artery Disease Patients

Aging Cell, EarlyView.
In male patients undergoing CABG surgery, pretreatment with quercetin suppressed inflammaging and its associated inflammation, leading to improved endothelium‐dependent relaxation (measured ex vivo) and reducing new onset of post‐operative atrial fibrillation.
Pauline Mury, Olina Dagher, Annik Fortier, Ariel Diaz, Yoan Lamarche, Pierre‐Emmanuel Noly, Marina Ibrahim, Pierre Pagé, Philippe Demers, Denis Bouchard, Pierre‐Luc Bernier, Nancy Poirier, Emmanuel Moss, Nicolas Durrleman, Hughes Jeanmart, Michel Pellerin, Guillaume Lettre, Nathalie Thorin‐Trescases, Michel Carrier, Eric Thorin   +19 more
wiley   +1 more source

The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila [PDF]

, 2007
Cristina Molnar, Helena Holguín, Federico Mayor, Ana Ruiz‐Gómez, José F. de Celis   +4 more
openalex   +1 more source

The Transcriptome Trajectory Reveals Sex‐ and Age‐Dependent Changes in the Mouse Adrenal Gland

Aging Cell, EarlyView.
This comprehensive RNA‐seq dataset reveals the sex‐ and age‐dependent gene expression profile of the mouse adrenal gland. It helps identify novel marker genes of the adrenal inner cortex, offering new insights into the organ's development and aging process.
Hui Wang, Ben Maggard, Huifei Sophia Zheng, Yuan Kang, Chen‐Che Jeff Huang   +4 more
wiley   +1 more source

Protein Kinase A, not Epac, Suppresses Hedgehog Activity and Regulates Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia Cells [PDF]

, 2007
Zhenyu Ji, Fang Mei, Betty H. Johnson, E. Brad Thompson, Xiaodong Cheng   +4 more
openalex   +1 more source

Skeletal Maturity and Age‐Related Changes in Immune Cells and Circulatory Factors Impair Large‐Scale Bone Regeneration

Aging Cell, EarlyView.
Although the ribs are the only human bones capable of regenerating large‐scale defects, this remarkable ability declines with skeletal maturity and age. Here, we reproduce skeletal maturity and age‐related phenotypic changes in a mouse model of rib resection.
Luciana Yamamoto de Almeida, Catharine Dietrich, Ashleigh S. Hanner, Katelyn M. McTighe, Daniel Martin, NIDCD/NIDCR Genomics and Computational Biology Core, Todd Fairbanks, Thomas M. Link, John M. Le, Natasha Curry, Priyam Jani, Xin Gao, Wenli Yu, Francesca V. Mariani, Olivier Duverger, Janice S. Lee   +15 more
wiley   +1 more source

Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif [PDF]

, 2008
Thomas R. Bürglin
openalex   +1 more source

The Ecological Genome Project and the Promises of Ecogenomics for Society: Realising a Shared Vision as One Health

Bioethics, EarlyView.
ABSTRACT This paper develops a vision for The Ecological Genome Project: an aspirational, global endeavour to connect human genomic sciences with the ethos of ecological sciences. The Project's goal is to strengthen interdisciplinary networks that relate to diverse initiatives using genomic technologies, with respect to shared ethical frameworks and ...
Benjamin Capps, Ruth Chadwick, Yann Joly, Claire Lajaunie, Iva Hauptmannova, Susannah Mackenzie, John. J. Mulvihill, Elizabeth Mumford, Sonja A. Rasmussen, Kunal Sanghavi, Donrich W. Thaldar, James Yeates, Maud C. Quinzin, Zohar Lederman   +13 more
wiley   +1 more source

The acetylation GLI1 affects arsenical-induced renal fibrosis by mediating the Hedgehog signalling pathway

Ecotoxicology and Environmental Safety
Arsenic exposure by drinking water is a key challenge in the field of public health worldwide. Research has found a connection between arsenic exposure and renal fibrosis, yet the mechanisms behind this are still unclear. In this study, rats were exposed
Pinya Liu, Yating Wang, Peiyu Jin, Qing Zhou, Liang Pei, Shuhua Xi   +5 more
doaj  

A luminal non‐coding RNA‐based genomic classifier confirms favourable outcomes in patients with clinically organ‐confined bladder cancer treated with radical cystectomy

BJU International, Volume 135, Issue 4, Page 648-656, April 2025.
Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong, James A. Proudfoot, Siamak Daneshmand, Robert S. Svatek, Vikram Narayan, Ewan A. Gibb, Elai Davicioni, Shreyas Joshi, Aaron Dahmen, Roger Li, Brant A. Inman, Paras Shah, Iftach Chaplin, Jonathan Wright, Yair Lotan   +14 more
wiley   +1 more source