Dual and opposing roles of primary cilia in medulloblastoma development. [PDF]
, 2009 Recent work has shown that primary cilia are essential for Hedgehog (Hh) signaling during mammalian development. It is also known that aberrant Hh signaling can lead to cancer, but the role of primary cilia in oncogenesis is not known. Cerebellar granule
Alvarez-Buylla, Arturo +5 more
core
Sonic hedgehog signaling during digit pattern duplication after application of recombinant protein and expressing cells [PDF]
, 1999 Naoyuki Wada +2 more
openalex +1 more source
Targeting gut microbiota as a therapeutic approach for neurodegenerative diseases
Neuroprotection, EarlyView.The abstract depicts the gut‐brain axis, illustrating the bidirectional communication between the gastrointestinal tract and the central nervous system. Probiotics can induce the production of neurotrophins, neurotransmitters, SCFAs, and contribute to increased antioxidant levels, which can benefit brain health. In contrast, antibiotics can disrupt the
Tobiloba S. Olajide +1 more
wiley +1 more source
Hedgehogs for neutral dissipative germs of holomorphic diffeomorphisms of $(\mathbb{C}^{2},0)$ [PDF]
arXiv, 2016 We prove the existence of hedgehogs for germs of complex analytic diffeomorphisms of $(\mathbb{C}^{2},0)$ with a semi-neutral fixed point at the origin, using topological techniques. This approach also provides an alternative proof of a theorem of P\'erez-Marco on the existence of hedgehogs for germs of univalent holomorphic maps of $(\mathbb{C},0 ...
arxiv
Sonic Hedgehog–Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System [PDF]
, 2000 Q. Richard Lu +8 more
openalex +1 more source
People and Nature, EarlyView.Abstract Overexploitation of wildlife is pervasive in many tropical regions, and in addition to being a significant conservation and sustainability concern, it has received global attention given discussions over the origins of zoonotic disease outbreaks.
Franklin T. Simo +8 more
wiley +1 more source
Hedgehog components are overexpressed in a series of liver cancer cases
Scientific ReportsLiver cancers, including hepatocellular carcinoma (HCC), are the sixth most common cancer and the third leading cause of cancer-related death worldwide, representing a global public health problem. This study evaluated nine patients with HCC.
Caroline Brandi Schlaepfer Sales +12 more
doaj +1 more source
Expression of Indian Hedgehog, Parathyroid Hormone-Related Protein, and Their Receptors in the Postnatal Growth Plate of the Rat: Evidence for a Locally Acting Growth Restraining Feedback Loop After Birth [PDF]
, 2000 Bram C. J. van der Eerden +4 more
openalex +1 more source
Precision Radiation Oncology, EarlyView.Abstract Oral Squamous Cell Carcinoma (OSCC) is the most prevalent form of oral cancer, constituting over 90% of reported cases. This malignancy commonly infiltrates bone, making bone invasion a significant clinical issue. OSCC may invade bone via either an infiltrative or erosive pattern, with the pattern of invasion closely correlating with the ...
Smrithy Sivadas K +4 more
wiley +1 more source
Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein [PDF]
, 2000 Philip W. Ingham +6 more
openalex +1 more source