Palmitoylation of Hedgehog proteins. [PDF]
Vitam Horm, 2012 Buglino JA, Resh MD.
europepmc +1 more source
Drosophila Costal1 Mutations Are Alleles of Protein Kinase A That Modulate Hedgehog Signaling [PDF]
, 2004 Lara S. Collier +3 more
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Human efferent ductules and epididymis display unique cell lineages with motile and primary cilia
Andrology, Volume 13, Issue 4, Page 894-910, May 2025.Abstract Background Previous research has illustrated the role of cilia as mechanical and sensory antennae in various organs within the mammalian male reproductive system across different developmental stages. Despite their significance in both organ development and homeostasis, primary cilia in the human male reproductive excurrent duct have been ...
Ludovic Vinay +2 more
wiley +1 more source
Phosphorylation of the fused protein kinase in response to signaling from hedgehog.
, 1996 Pascal P. Thérond +3 more
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Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates [PDF]
, 2004 Miao-Hsueh Chen +4 more
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BJU International, Volume 135, Issue 4, Page 648-656, April 2025.Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong +14 more
wiley +1 more source
Natural products targeting tumour angiogenesis
British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu +2 more
wiley +1 more source
Hedgehog Proteins Consume Steroidal CYP17A1 Antagonists: Potential Therapeutic Significance in Advanced Prostate Cancer. [PDF]
ChemMedChem, 2016 Bordeau BM, Ciulla DA, Callahan BP.
europepmc +1 more source
Aberrant methylation of the human hedgehog interacting protein (HHIP) gene in pancreatic neoplasms [PDF]
, 2005 Seán T. Martin +7 more
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The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
British Journal of Pharmacology, EarlyView.Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf +10 more
wiley +1 more source