Results 211 to 220 of about 93,686 (252)

Protein modifications in Hedgehog signaling

BioEssays, 2021
AbstractThe complexity of the Hedgehog (Hh) signaling cascade has increased over the course of evolution; however, it does not suffice to accommodate the dynamic yet robust requirements of differential Hh signaling activity needed for embryonic development and adult homeostatic maintenance.
Min Liu, Ying Su, Jingyu Peng, Alan Jian Zhu   +3 more
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Serum Proteins in the Hedgehog

Acta Physiologica Scandinavica, 1967
AbstractHedgehog serum proteins were studied by physical, chemical and immunological methods. The paper electrophoretic and immunoelectrophoretic patterns did not differ greatly from those of human serum. In paper electrophoresis two beta‐bands were found, the beta2‐band being the most conspicuous. In the immunoelectrophoretic pattern, the form of the “
B, Larsen, O, Tönder
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Autoproteolysis in hedgehog protein biogenesis

Science, 1994
Extracellular signaling proteins encoded by the hedgehog (hh) multigene family are responsible for the patterning of a variety of embryonic structures in vertebrates and invertebrates. The Drosophila hh gene has now been shown to generate two predominant protein species that are derived by an internal autoproteolytic cleavage of a larger precursor ...
J J, Lee, S C, Ekker, D P, von Kessler, J A, Porter, B I, Sun, P A, Beachy   +5 more
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Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

Nature, 1999
The Hedgehog signalling pathway is essential for the development of diverse tissues during embryogenesis. Signalling is activated by binding of Hedgehog protein to the multipass membrane protein Patched (Ptc). We have now identified a novel component in the vertebrate signalling pathway, which we name Hip (for Hedgehog-interacting protein) because of ...
P T, Chuang, A P, McMahon
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Regulation ofnetrin-1aExpression by Hedgehog Proteins

Molecular and Cellular Neuroscience, 1998
Netrins, a family of growth cone guidance molecules, are expressed both in the ventral neural tube and in subsets of mesodermal cells. In an effort to better understand the regulation of netrins, we examined the expression of netrin-1a in mutant cyclops, no tail, and floating head zebrafish embryos, in which axial midline structures are perturbed ...
Lauderdale, J., Pasquali, S., Fazel, R., van Eeden, F. ; https://orcid.org/0000-0003-3483-8269, Schauerte, H., Haffter, P., Kuwada, J.   +6 more
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Serum proteins in young hedgehogs

Journal of Zoology, 1970
Four serum protein components are present at birth: α‐, β‐ and γ‐globulins and albumin.The preferential transfer of γ rather than β‐globulin, which occurs both prenatally and postnatally in this species, is reflected in the initial amounts of these proteins present at birth and in the relatively rapid increase in the concentration of γ‐globulin which ...
Morris, B., Rudge, G.
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Translating Hedgehog in Cancer: Controlling Protein Synthesis

Trends in Molecular Medicine, 2016
Developmental Hedgehog (Hh) signaling is found deregulated in a broad spectrum of human malignancies and, thus, is an attractive target for cancer therapy. Currently available Hh inhibitors have shown the rapid occurrence of drug resistance, due to altered signaling in collateral pathways.
D'AMICO, Davide, CANETTIERI, Gianluca
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Sonic Hedgehog Protein

CNS Drugs, 1998
Sonic hedgehog is a member of a newly discovered family of molecules that are active during development in vertebrates. Sonic hedgehog induces development of key CNS neuronal cell types, including the dopaminergic neurons that are destroyed in Parkinson's disease.
K, Pang, T D, Ingolia
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The mammalian Hedgehog pathway is modulated by ANP32 proteins

Biochemical and Biophysical Research Communications, 2021
Medulloblastoma (MB) is the most common malignant brain tumor in children. Transcriptional profiling has so far delineated four major MB subgroups of which one is driven by uncontrolled Hedgehog (Hh) signaling (SHH-MB). This pathway is amenable to drug targeting, yet clinically approved compounds exclusively target the transmembrane component ...
Anna Hupfer, Anna Brichkina, Till Adhikary, Matthias Lauth   +3 more
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Purifying the Hedgehog Protein and its Variants

2007
The purification of recombinant versions of the N-terminal signaling fragment of Sonic hedgehog (ShhN) from E. coli, Hi-5 insect cells, yeast, and mammalian cell sources reveals diverse post-translational modifications that affect the potency of the purified protein. Modifications to the N-terminal cysteine with fatty acyl groups results in significant
Darren P, Baker, Frederick R, Taylor, R Blake, Pepinsky   +2 more
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