Results 221 to 230 of about 93,686 (252)
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Age-dependent effects of hedgehog protein on chondrocytes
The Journal of Bone and Joint Surgery. British volume, 1999Bone morphogenetic protein (BMP) has a crucial role in osteochondrogenesis of bone formation as well as in the repair of fractures. The interaction between hedgehog protein and BMPs is inferred from recent molecular studies. Hedgehog genes encode secreted proteins which mediate patterning and growth during skeletal development.
M, Iwasaki, A, Jikko, A X, Le
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Hedgehog signalling in the mouse requires intraflagellar transport proteins
Nature, 2003Intraflagellar transport (IFT) proteins were first identified as essential factors for the growth and maintenance of flagella in the single-celled alga Chlamydomonas reinhardtii. In a screen for embryonic patterning mutations induced by ethylnitrosourea, here we identify two mouse mutants, wimple (wim) and flexo (fxo), that lack ventral neural cell ...
Danwei Huangfu, Aimin Liu, Lee Niswander
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Annals of the New York Academy of Sciences, 2006
Abstract: Hedgehog (HH) is a secreted protein named for the bristle phenotype observed in Drosophila embryos that lack the corresponding gene. Three homologs have been characterized in vertebrates, all which have critical roles in the development of multiple organ systems.
James A, Waschek +3 more
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Abstract: Hedgehog (HH) is a secreted protein named for the bristle phenotype observed in Drosophila embryos that lack the corresponding gene. Three homologs have been characterized in vertebrates, all which have critical roles in the development of multiple organ systems.
James A, Waschek +3 more
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Hedgehog and Protein Kinase C Signaling
2011Hedgehog (HH) and protein kinase C (PKC) signaling pathways are critically involved in embryonic development, stem cells, and cancer cells. Recent evidence has shown the regulation of these phenotypes by the crosstalk between the HH and PKC pathways. Among the PKC family, PKCα and PKCδ are important isoforms involved in HH pathway regulation.
Jing Li, B. Mark Evers
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Targeting of proteins to membranes through hedgehog auto-processing
Nature Biotechnology, 2003Hedgehog proteins use an auto-processing strategy to generate cholesterol-conjugated peptide products that act as extracellular ligands in a number of developmental signaling pathways. We describe an approach that takes advantage of the hedgehog auto-processing reaction to carry out intracellular modification of heterologous proteins, resulting in ...
Sylvie, Vincent +3 more
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Regulatory mechanisms governing GLI proteins in hedgehog signaling
Anatomical Science InternationalThe Hedgehog (Hh) signaling pathway is critical for regulating cell growth, survival, fate determination, and the overall patterning of both vertebrate and invertebrate body plans. Aberrations in Hh signaling are associated with congenital abnormalities and tumorigenesis. In vertebrates, Hh signaling depends uniquely on primary cilia, microtubule-based
Saishu Yoshida, Kiyotsugu Yoshida
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Protein Degradation Regulates Sonic Hedgehog Signals
Science's STKE, 2006Huntzicker et al. have discovered a new layer of regulation in the Sonic hedgehog signaling pathway, which is known to contribute to birth defects and cancer in humans. The Gli transcription factors are mediators of Sonic hedgehog-dependent changes in gene expression.
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Protein Kinase A Activity and Hedgehog Signaling Pathway
2012Protein kinase A (PKA) is a well-known kinase that plays fundamental roles in a variety of biological processes. In Hedgehog-responsive cells, PKA plays key roles in proliferation and fate specification by modulating the transduction of Hedgehog signaling. In the absence of Hedgehog, a basal level of PKA activity represses the transcription of Hedgehog
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Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
Nature Reviews Clinical Oncology, 2015Lucio Miele, Sherry X Yang, S Percy Ivy
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The mechanisms of Hedgehog signalling and its roles in development and disease
Nature Reviews Molecular Cell Biology, 2013James Briscoe
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