Results 261 to 270 of about 92,914 (298)

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

Nature, 1999
The Hedgehog signalling pathway is essential for the development of diverse tissues during embryogenesis. Signalling is activated by binding of Hedgehog protein to the multipass membrane protein Patched (Ptc). We have now identified a novel component in the vertebrate signalling pathway, which we name Hip (for Hedgehog-interacting protein) because of ...
P T, Chuang, A P, McMahon
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Hedgehog signalling in the mouse requires intraflagellar transport proteins

Nature, 2003
Intraflagellar transport (IFT) proteins were first identified as essential factors for the growth and maintenance of flagella in the single-celled alga Chlamydomonas reinhardtii. In a screen for embryonic patterning mutations induced by ethylnitrosourea, here we identify two mouse mutants, wimple (wim) and flexo (fxo), that lack ventral neural cell ...
Danwei, Huangfu, Aimin, Liu, Andrew S, Rakeman, Noel S, Murcia, Lee, Niswander, Kathryn V, Anderson   +5 more
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Targeting of proteins to membranes through hedgehog auto-processing

Nature Biotechnology, 2003
Hedgehog proteins use an auto-processing strategy to generate cholesterol-conjugated peptide products that act as extracellular ligands in a number of developmental signaling pathways. We describe an approach that takes advantage of the hedgehog auto-processing reaction to carry out intracellular modification of heterologous proteins, resulting in ...
Sylvie, Vincent, Abraham, Thomas, Bradley, Brasher, John D, Benson   +3 more
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Protein modifications in Hedgehog signaling

BioEssays, 2021
AbstractThe complexity of the Hedgehog (Hh) signaling cascade has increased over the course of evolution; however, it does not suffice to accommodate the dynamic yet robust requirements of differential Hh signaling activity needed for embryonic development and adult homeostatic maintenance.
Min Liu, Ying Su, Jingyu Peng, Alan Jian Zhu   +3 more
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Serum Proteins in the Hedgehog

Acta Physiologica Scandinavica, 1967
AbstractHedgehog serum proteins were studied by physical, chemical and immunological methods. The paper electrophoretic and immunoelectrophoretic patterns did not differ greatly from those of human serum. In paper electrophoresis two beta‐bands were found, the beta2‐band being the most conspicuous. In the immunoelectrophoretic pattern, the form of the “
B, Larsen, O, Tönder
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Autoproteolysis in hedgehog protein biogenesis

Science, 1994
Extracellular signaling proteins encoded by the hedgehog (hh) multigene family are responsible for the patterning of a variety of embryonic structures in vertebrates and invertebrates. The Drosophila hh gene has now been shown to generate two predominant protein species that are derived by an internal autoproteolytic cleavage of a larger precursor ...
J J, Lee, S C, Ekker, D P, von Kessler, J A, Porter, B I, Sun, P A, Beachy   +5 more
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Regulation ofnetrin-1aExpression by Hedgehog Proteins

Molecular and Cellular Neuroscience, 1998
Netrins, a family of growth cone guidance molecules, are expressed both in the ventral neural tube and in subsets of mesodermal cells. In an effort to better understand the regulation of netrins, we examined the expression of netrin-1a in mutant cyclops, no tail, and floating head zebrafish embryos, in which axial midline structures are perturbed ...
Lauderdale, J., Pasquali, S., Fazel, R., van Eeden, F. ; https://orcid.org/0000-0003-3483-8269, Schauerte, H., Haffter, P., Kuwada, J.   +6 more
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Serum proteins in young hedgehogs

Journal of Zoology, 1970
Four serum protein components are present at birth: α‐, β‐ and γ‐globulins and albumin.The preferential transfer of γ rather than β‐globulin, which occurs both prenatally and postnatally in this species, is reflected in the initial amounts of these proteins present at birth and in the relatively rapid increase in the concentration of γ‐globulin which ...
Morris, B., Rudge, G.
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Translating Hedgehog in Cancer: Controlling Protein Synthesis

Trends in Molecular Medicine, 2016
Developmental Hedgehog (Hh) signaling is found deregulated in a broad spectrum of human malignancies and, thus, is an attractive target for cancer therapy. Currently available Hh inhibitors have shown the rapid occurrence of drug resistance, due to altered signaling in collateral pathways.
D'AMICO, Davide, CANETTIERI, Gianluca
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Sonic Hedgehog Protein

CNS Drugs, 1998
Sonic hedgehog is a member of a newly discovered family of molecules that are active during development in vertebrates. Sonic hedgehog induces development of key CNS neuronal cell types, including the dopaminergic neurons that are destroyed in Parkinson's disease.
K, Pang, T D, Ingolia
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