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The mammalian Hedgehog pathway is modulated by ANP32 proteins
Biochemical and Biophysical Research Communications, 2021Medulloblastoma (MB) is the most common malignant brain tumor in children. Transcriptional profiling has so far delineated four major MB subgroups of which one is driven by uncontrolled Hedgehog (Hh) signaling (SHH-MB). This pathway is amenable to drug targeting, yet clinically approved compounds exclusively target the transmembrane component ...
Anna Hupfer +3 more
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Purifying the Hedgehog Protein and its Variants
2007The purification of recombinant versions of the N-terminal signaling fragment of Sonic hedgehog (ShhN) from E. coli, Hi-5 insect cells, yeast, and mammalian cell sources reveals diverse post-translational modifications that affect the potency of the purified protein. Modifications to the N-terminal cysteine with fatty acyl groups results in significant
Darren P, Baker +2 more
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Age-dependent effects of hedgehog protein on chondrocytes
The Journal of Bone and Joint Surgery. British volume, 1999Bone morphogenetic protein (BMP) has a crucial role in osteochondrogenesis of bone formation as well as in the repair of fractures. The interaction between hedgehog protein and BMPs is inferred from recent molecular studies. Hedgehog genes encode secreted proteins which mediate patterning and growth during skeletal development.
M, Iwasaki, A, Jikko, A X, Le
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Annals of the New York Academy of Sciences, 2006
Abstract: Hedgehog (HH) is a secreted protein named for the bristle phenotype observed in Drosophila embryos that lack the corresponding gene. Three homologs have been characterized in vertebrates, all which have critical roles in the development of multiple organ systems.
James A, Waschek +3 more
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Abstract: Hedgehog (HH) is a secreted protein named for the bristle phenotype observed in Drosophila embryos that lack the corresponding gene. Three homologs have been characterized in vertebrates, all which have critical roles in the development of multiple organ systems.
James A, Waschek +3 more
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Hedgehog and Protein Kinase C Signaling
2011Hedgehog (HH) and protein kinase C (PKC) signaling pathways are critically involved in embryonic development, stem cells, and cancer cells. Recent evidence has shown the regulation of these phenotypes by the crosstalk between the HH and PKC pathways. Among the PKC family, PKCα and PKCδ are important isoforms involved in HH pathway regulation.
Jing Li, B. Mark Evers
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Regulatory mechanisms governing GLI proteins in hedgehog signaling
Anatomical Science InternationalThe Hedgehog (Hh) signaling pathway is critical for regulating cell growth, survival, fate determination, and the overall patterning of both vertebrate and invertebrate body plans. Aberrations in Hh signaling are associated with congenital abnormalities and tumorigenesis. In vertebrates, Hh signaling depends uniquely on primary cilia, microtubule-based
Saishu Yoshida, Kiyotsugu Yoshida
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Protein Degradation Regulates Sonic Hedgehog Signals
Science's STKE, 2006Huntzicker et al. have discovered a new layer of regulation in the Sonic hedgehog signaling pathway, which is known to contribute to birth defects and cancer in humans. The Gli transcription factors are mediators of Sonic hedgehog-dependent changes in gene expression.
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Protein Kinase A Activity and Hedgehog Signaling Pathway
2012Protein kinase A (PKA) is a well-known kinase that plays fundamental roles in a variety of biological processes. In Hedgehog-responsive cells, PKA plays key roles in proliferation and fate specification by modulating the transduction of Hedgehog signaling. In the absence of Hedgehog, a basal level of PKA activity represses the transcription of Hedgehog
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Cellular and molecular mechanisms of Hedgehog signalling
Nature Reviews Molecular Cell Biology, 2023Yunxiao Zhang, Philip A Beachy
exaly
The mechanisms of Hedgehog signalling and its roles in development and disease
Nature Reviews Molecular Cell Biology, 2013James Briscoe
exaly