Results 81 to 90 of about 92,914 (298)
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane
Cell Reports, 2019 Summary: Attachment of palmitate to the N terminus of Sonic hedgehog (Shh) is essential for Shh signaling. Shh palmitoylation is catalyzed on the luminal side of the endoplasmic reticulum (ER) by Hedgehog acyltransferase (Hhat), an ER-resident enzyme ...
James J. Asciolla, Marilyn D. Resh
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2020 Background The mechanism underlying sorafenib resistance in hepatocellular carcinoma (HCC) remains unclear. Accumulating evidence suggests that tumor-initiating cells (TICs) are a pivotal driving force. Both CD44 and Hedgehog signaling play crucial roles
Siqi Wang +8 more
doaj +1 more source
Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling. [PDF]
PLoS Genetics, 2011 The non-visual ß-arrestins are cytosolic proteins highly conserved across species that participate in a variety of signalling events, including plasma membrane receptor degradation, recycling, and signalling, and that can also act as scaffolding for ...
Cristina Molnar +5 more
doaj +1 more source
The Role of GLI-1 in Endocrine Resistant Breast Cancer [PDF]
, 2014 Estrogen receptor positive (ER+) and estrogen receptor negative (ER-) are two major types of breast cancer. For women with ER+ positive breast cancer, patients are treated with the antiestrogenic compounds, tamoxifen or faslodex for five years ...
Rudolph, Mark
core
Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide. [PDF]
, 2018 Resistance to chemotherapy substantially hinders successful glioblastoma (GBM) treatment, contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy, temozolomide (TMZ), arises from numerous signaling pathways that are ...
Day, Emily S +5 more
core +1 more source
Advanced Science, EarlyView.Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang +3 more
wiley +1 more source
PLoS ONE, 2007 BackgroundHedgehog signalling, interpreted in receiving cells by Gli transcription factors, plays a central role in the development of vertebrate and Drosophila embryos. Many aspects of the signalling pathway are conserved between these lineages, however
Sebastian M Shimeld +3 more
doaj +1 more source
Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding [PDF]
, 2015 The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing ...
Adair +63 more
core +3 more sources
Dispatched protein releases Hedgehog from cells [PDF]
Genome Biology, 2000 A novel Drosophila segment polarity gene is identified and shown to be required for release of Hedgehog protein from secreting cells.
openaire +1 more source