Results 141 to 150 of about 247,901 (376)

The Hedgehog Signaling Pathway: Where Did It Come From?

PLoS Biology, 2009
The Hedgehog signaling pathway plays a crucial role in development and disease. Its putative origins in an ancient system involved in regulating bacterial lipid transport and homeostasis offers clues about how the pathway might work today.
George Hausmann, Christian von Mering, Christian von Mering, Konrad Basler   +3 more
openaire   +5 more sources

Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly

Cytoskeleton, EarlyView.
ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley   +1 more source

The Proteasome and Cul3-Dependent Protein Ubiquitination Is Required for Gli Protein-Mediated Activation of Gene Expression in the Hedgehog Pathway

Cells
Many cellular processes are regulated by proteasome-mediated protein degradation, including regulation of signaling pathways and gene expression. Among the pathways regulated by the ubiquitin–proteasome system is the Hedgehog pathway and its downstream ...
Tomasz Uśpieński, Paweł Niewiadomski
doaj   +1 more source

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells [PDF]

, 2018
Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development.
Agnese Po, Andrea Carai, Angela Mastronuzzi, Elisabetta Ferretti, Elisabetta Ferretti, Enrico De Smaele, Evelina Miele, Felice Giangaspero, Felice Giangaspero, Franco Locatelli, Franco Locatelli, Luana Abballe, Marta Moretti, Zein Mersini Besharat   +13 more
core   +9 more sources

Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development

Developmental Dynamics, EarlyView.
Abstract Cilia are specialized structures found on a variety of mammalian cells, with variable roles in the transduction of mechanical and biological signals (by primary cilia, PC), as well as in the generation of fluid flow (by motile cilia). Their critical role in the establishment of a left–right axis in early development is well described, as well ...
Stephen Spurgin, Ange Michelle Nguimtsop, Fatima N. Chaudhry, Sylvia N. Michki, Jocelynda Salvador, M. Luisa Iruela‐Arispe, Jarod A. Zepp, Saikat Mukhopadhyay, Ondine Cleaver   +8 more
wiley   +1 more source

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

, 2019
The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years.
Aleithe, S., Brosch, M., Brusch, L., Damm, G., Gajowski, R., Gebhardt, R., Hampe, J., Hoehme, S., Hoffmann, U., Kolbe, E., Kücken, M., Matz-Soja, M., Meierhofer, D., Ott, F., Rennert, C., Schafmayer, C., Seehofer, D., Seifert, M., Spormann, L., Stöpel, C., von Schoenfels, W.   +20 more
core   +1 more source

Maml1 acts cooperatively with Gli proteins to regulate Sonic hedgheog signaling pathway [PDF]

, 2017
Sonic hedgehog (Shh) signaling is essential for proliferation of cerebellar granule cell progenitors (GCPs) and its misregulation is linked to various disorders, including cerebellar cancer medulloblastoma.
BELLAVIA, Diana, BUFALIERI, FRANCESCA, CHECQUOLO, Saula, DI MARCOTULLIO, LUCIA, FELLI, MARIA PIA, LAUER, DIETER MATTHIAS, NARDOZZA, FRANCESCA, PALERMO, ROCCO, PELULLO, MARIA, QUARANTA, ROBERTA, SCREPANTI, Isabella, TALORA, Claudio, VACCA, Alessandra, ZEMA, SABRINA   +13 more
core   +1 more source

The role of the PTHrP/Ihh feedback loop in the unusual growth plate location in mammalian metatarsals and pisiforms

Developmental Dynamics, EarlyView.
Abstract Background Longitudinal skeletal growth takes place in the cartilaginous growth plates. While growth plates are found at either end of conventional long bones, they occur at a variety of locations in the mammalian skeleton. For example, the metacarpals and metatarsals (MT) in the hands and feet form only a single growth plate at one end, and ...
Philip L. Reno, Sherrie Wallace, Sarah N. Doelp, Maria Biancaniello, Kelsey M. Kjosness   +4 more
wiley   +1 more source

Smooth Combs Inside Hedgehogs [PDF]

arXiv, 2009
We use techniques of tube-log Riemann surfaces due to R.Perez-Marco to construct a hedgehog containing smooth $C^{\infty}$ combs. The hedgehog is a common hedgehog for a family of commuting non-linearisable holomorphic maps with a common indifferent fixed point. The comb is made up of smooth curves, and is transversally bi-H\"older regular.
arxiv  

A head start: The relationship of placental factors to craniofacial and brain development

Developmental Dynamics, EarlyView.
Abstract In recent years, the importance of placental function for fetal neurodevelopment has become increasingly studied. This field, known as neuroplacentology, has greatly expanded possible etiologies of neurodevelopmental disorders by exploring the influence of placental function on brain development.
Annemarie Jenna Carver, Martine Dunnwald, Hanna Elizabeth Stevens   +2 more
wiley   +1 more source