Results 161 to 170 of about 247,901 (376)
Exploration, EarlyView.Schematic illustration of structural and functional biomimicry. The upper part shows BP with various structures such as monolayered, surface‐microstructural, bilayered and multilayered. The bottom part exhibits BP with different functions including immune regulation, drugs/cells/factors/ions loading, as well as bioelectrical stimulation and ...
Yuhan Du +7 more
wiley +1 more source
Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein [PDF]
, 2000 Philip W. Ingham +6 more
openalex +1 more source
Scientific Reports, 2017 The Hippo pathway is conserved and plays important roles in organ size control. The core components of the Hippo pathway are two kinases Hippo (Hpo), Warts (Wts), and a transcription-co-activator Yorkie (Yki). Yki activity is regulated by phosphorylation,
Ta-Hsing Hsu +5 more
doaj +1 more source
Gli Proteins: Regulation in Development and Cancer
Cells, 2019 Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer. We review the molecular mechanisms of Gli protein regulation
Paweł Niewiadomski +5 more
doaj +1 more source
The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway. [PDF]
, 2002 Barbara Stecca, Ariel Ruiz i Altaba
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Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
The Radial-Hedgehog Solution in Landau--de Gennes' theory [PDF]
arXiv, 2010 We study the radial-hedgehog solution in a three-dimensional spherical droplet, with homeotropic boundary conditions, within the Landau-de Gennes theory for nematic liquid crystals. The radial-hedgehog solution is a candidate for a globally stable configuration in this model framework and is also a prototype configuration for studying isolated point ...
arxiv
Interdisciplinary Medicine, EarlyView.This article evaluates the therapeutic potential of extracellular vesicle‐like particles derived from Chinese herbal medicine (CHM‐EVLP) for a range of diseases. It underscores the significance of traditional Chinese medicine in the development of innovative formulations.
Ying‐qi Cao +6 more
wiley +1 more source
SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation
Cell Death DiscoveryThe transcription factor GLI1 is the main and final effector of the Hedgehog signaling pathway, which is involved in embryonic development, cell proliferation and stemness.
Fabio Bordin +14 more
doaj +1 more source
Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer. [PDF]
, 2019 BackgroundPancreatic cancer is one of the most lethal malignancies due to frequent late diagnosis, aggressive tumor growth and metastasis formation.
Horne, David A +4 more
core +1 more source