Human Organoids and Their Application in Tumor Models, Disease Modeling, and Tissue Engineering
Medicine Bulletin, EarlyView.ABSTRACT Organoid technology has revolutionized biomedical research, disease modeling, drug discovery, and regenerative medicine by providing three‐dimensional (3D) organ‐like structures that closely mimic native human tissues. Derived from pluripotent and adult stem cells, organoids replicate the structural, cellular, and functional characteristics of
Siyuan Song, Zheng Liu, Yi Wang, Bo Gong
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Frontiers in PharmacologyIntroductionLiver fibrosis is a significant global health burden that lacks effective therapies. It can progress to cirrhosis and hepatocellular carcinoma (HCC).
Amir Mohamed Abdelhamid +24 more
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Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway [PDF]
, 2005 Rudolph D. Paladini +4 more
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Targeting gut microbiota as a therapeutic approach for neurodegenerative diseases
Neuroprotection, EarlyView.The abstract depicts the gut‐brain axis, illustrating the bidirectional communication between the gastrointestinal tract and the central nervous system. Probiotics can induce the production of neurotrophins, neurotransmitters, SCFAs, and contribute to increased antioxidant levels, which can benefit brain health. In contrast, antibiotics can disrupt the
Tobiloba S. Olajide +1 more
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Molecular mechanisms of Eda‐mediated adaptation to freshwater in threespine stickleback
Molecular Ecology, EarlyView., 2023 Abstract A main goal of evolutionary biology is to understand the genetic basis of adaptive evolution. Although the genes that underlie some adaptive phenotypes are now known, the molecular pathways and regulatory mechanisms mediating the phenotypic effects of those genes often remain a black box.
Carlos E. Rodríguez‐Ramírez +5 more
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Sufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae [PDF]
, 2014 Poster presentation - Theme 3: Development & stem cellsThe Sonic Hedgehog pathway plays important roles in mammalian inner ear development. Mutations of Shh, Smo and Gli3 lead to severe defects in mouse inner ear morphogenesis.
Hui, CC +4 more
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A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury
Neuroprotection, EarlyView.This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
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The Cell Surface Membrane Proteins Cdo and Boc Are Components and Targets of the Hedgehog Signaling Pathway and Feedback Network in Mice [PDF]
, 2006 Toyoaki Tenzen +5 more
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Antbears and underground melons: A highly specialized seed dispersal mutualism mediated by scent
PLANTS, PEOPLE, PLANET, EarlyView.Seed dispersal is critical for the establishment and persistence of populations of most plant species. We investigated the seed dispersal biology of an African melon, Cucumis humifructus, which is closely related to cultivated cucumbers and watermelons but differs in that it buries its fruits deep underground.
Steven D. Johnson +2 more
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Investigational agents in metastatic basal cell carcinoma: focus on vismodegib
Journal of Experimental Pharmacology, 2012 Nicolas Batty,1 Ellen Kossoff,2 Grace K Dy11Department of Medicine, Roswell Park Cancer Center, Buffalo, NY, USA; 2Department of Pharmacy, Roswell Park Cancer Center, Buffalo, NY, USAAbstract: Vismodegib (GDC-0449, 2-chloro-N-(4-chloro-3-(pyridin-2-yl ...
Batty N, Kossoff E, Dy GK
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