Results 191 to 200 of about 247,901 (376)

Massive Infiltrative Osteolysis of the Mandible in Oral Squamous Cell Carcinoma: A Case Report with a Review of the Literature

Precision Radiation Oncology, EarlyView.
Abstract Oral Squamous Cell Carcinoma (OSCC) is the most prevalent form of oral cancer, constituting over 90% of reported cases. This malignancy commonly infiltrates bone, making bone invasion a significant clinical issue. OSCC may invade bone via either an infiltrative or erosive pattern, with the pattern of invasion closely correlating with the ...
Smrithy Sivadas K, Ananya Madiyal, Vidya Ajila, Krishna Sharan, Yashika Jain   +4 more
wiley   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Targeting the hedgehog signaling pathway to improve tendon-to-bone integration. [PDF]

Osteoarthritis Cartilage, 2023
Kamalitdinov TB, Fujino K, Keith Lang S, Jiang X, Madi R, Evans MK, Zgonis MH, Kuntz AF, Dyment NA.   +8 more
europepmc   +1 more source

Oncogenic KRAS Activates Hedgehog Signaling Pathway in Pancreatic Cancer Cells [PDF]

, 2007
Zhenyu Ji, Fang Mei, Jingwu Xie, Xiaodong Cheng   +3 more
openalex   +1 more source

Micro/Nanorobotics in Environmental Water Governance: Nanoengineering Strategies for Pollution Control

Small Structures, EarlyView.
Micro/nanorobots have been developed and deployed, revealing their state‐of‐the‐art applications in pollution detection and remediation. Innovative research progress includes collective behaviors, advanced propulsion mechanisms, and functionalization strategies that enhance their efficiency in diverse and complex aquatic environments, pointing toward ...
Yingyi Gan, Bin Wang, Yuan Lu
wiley   +1 more source

Role of hedgehog signaling in the pathogenesis and therapy of heterotopic ossification

Frontiers in Cell and Developmental Biology
Heterotopic ossification (HO) is a pathological process that generates ectopic bone in soft tissues. Hedgehog signaling (Hh signaling) is a signaling pathway that plays an important role in embryonic development and involves three ligands: sonic hedgehog
Yiran Pei, Yiran Pei, Fangzhou Liu, Fangzhou Liu, Yike Zhao, Yike Zhao, Hui Lin, Xiaoyan Huang   +7 more
doaj   +1 more source

Causal loop and Stock-Flow Modeling of Signal Transduction Pathways [PDF]

arXiv
System dynamics is a popular approach in many fields of science and technology, but it has not been investigated for cell signaling pathways yet. It is a well formulated methodology used to analyze the components of a system considering the cause-effect relationships.
arxiv  

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

, 1995
Chen‐Ming Fan, Jeffery A. Porter, Chin Chiang, David T. Chang, Philip A. Beachy, Marc Tessier‐Lavigne   +5 more
openalex   +1 more source

Improving the integration of artificial intelligence into existing ecological inference workflows

Methods in Ecology and Evolution, EarlyView.
Abstract Artificial intelligence (AI) has revolutionised the process of identifying species and individuals in audio recordings and camera trap images. However, despite developments in sensor technology, machine learning and statistical methods, a general AI‐assisted data‐to‐inference pipeline has yet to emerge. We argue that this is, in part, due to a
Amber Cowans, Xavier Lambin, Darragh Hare, Chris Sutherland   +3 more
wiley   +1 more source

The Role of Hedgehog Signaling Pathway in Head and Neck Squamous Cell Carcinoma. [PDF]

Cells, 2023
Cierpikowski P, Leszczyszyn A, Bar J.
europepmc   +1 more source