Results 281 to 290 of about 834,809 (383)

Aberrant Activation of the Hedgehog Signaling Pathway in Malignant Hematological Neoplasms

, 2011
Chi Young Ok, Rajesh R. Singh, Francisco Vega   +2 more
openalex   +1 more source

Probing the biological efficacy and mechanistic pathways of natural compounds in breast cancer therapy via the Hedgehog signaling pathway. [PDF]

J Pharm Anal
Cheng Y, Zhang W, Sun Q, Wang X, Shang Q, Liu J, Zhang Y, Liu R, Sun C.   +8 more
europepmc   +1 more source

Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone. [PDF]

Chemistry, 2022
Grigalunas M, Patil S, Krzyzanowski A, Pahl A, Flegel J, Schölermann B, Xie J, Sievers S, Ziegler S, Waldmann H.   +9 more
europepmc   +1 more source

Emerging roles for integrated stress response signaling in homeostasis

The FEBS Journal, EarlyView.
Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress‐adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of literature and presents several homeostatic functions of ISR in the absence of stress: (a) developmental processes (morphogenesis, differentiation, aging), (
Shyama Nandakumar, Lydia Grmai, Deepika Vasudevan   +2 more
wiley   +1 more source

Reappraisal of the Roles of the Sonic Hedgehog Signaling Pathway in Hepatocellular Carcinoma. [PDF]

Cancers (Basel)
Jeng KS, Chang CF, Tsang YM, Sheen IS, Jeng CJ.   +4 more
europepmc   +1 more source

Exploring the roles of conserved context‐dependent cis‐regulatory elements (cdCREs) in multicellularity, human health and disease

The FEBS Journal, EarlyView.
Conserved context‐dependent cis‐regulatory elements act as a major reservoir of disease‐associated polymorphisms in the human genome and are also affected by epigenetic change. This ‘state‐of‐the‐art’ review explores the latest developments in studying these enigmatic elements and how the effects of disease‐associated polymorphisms and environmentally ...
Andrew McEwan, Alexander Rattray, Greg Hutchings, Elizabeth Hay, Chris Murgatroyd, Alasdair MacKenzie   +5 more
wiley   +1 more source

Primary Cilia Formation Mediated by Hsa_Circ_0005185/OTUB1/RAB8A Complex Inhibits Prostate Cancer Progression by Suppressing Hedgehog Signaling Pathway. [PDF]

Adv Sci (Weinh)
Fan A, Zhang Y, Li Y, Meng W, Wu F, Pan W, Ma Z, Chen W.   +7 more
europepmc   +1 more source

Ageing versus developmental silencing: Answers from the epigenome

The FEBS Journal, EarlyView.
It is easier for young animals to regenerate damaged or missing tissues. In this Viewpoint, we propose that this is, in part, attributed to epigenetic changes, with chromatin becoming more closed and inaccessible as animals age. The timing of when this occurs differs depending on the tissue—some during the late developmental stages and others at the ...
Kirsten C. Sadler, Mekayla A. Storer, N. Sumru Bayin   +2 more
wiley   +1 more source

Characterization of Esrrb function in metastatic prostate cancer cells and transcriptional regulation of hedgehog-signaling pathway target genes [PDF]

, 2014
Lu Yuan
openalex   +1 more source

NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of H₂S into the synovium. [PDF]

J Nanobiotechnology
Zhu XX, Xu AJ, Cai WW, Han ZJ, Zhang SJ, Hou B, Wen YY, Cao XY, Li HD, Du YQ, Zhuang YY, Wang J, Hu XR, Bai XR, Su JB, Zhang AY, Lu QB, Gu Y, Qiu LY, Pan L, Sun HJ.   +20 more
europepmc   +1 more source