Results 151 to 160 of about 150,776 (304)
Advanced Science, EarlyView.We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang +19 more
wiley +1 more source
Live and Let Live: The Remarkable Story of HEK293 Cells [PDF]
Human Gene Therapy, 2020 openaire +2 more sources
Colocalization of mSlo1 and TRPV1 in HEK293 cells.
, 2013 A, Surface expression of mSlo1 and TRPV1. HEK293 cells were cotransfected with mSlo1-TagGFP (green) and TRPV1-myc (red). Confocal images of mSlo1-TagGFP (left panel) and TRPV1-myc (middle panel) have clearly green and red edges, respectively, and the ...
Ying Wu (19057) +10 more
core +1 more source
TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain
Advanced Science, EarlyView.TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando +2 more
wiley +1 more source
The opioid tramadol blocks the cardiac sodium channel Nav1.5 in HEK293 cells. [PDF]
Europace, 2023 Jia L, Veldkamp MW, Verkerk AO, Tan HL.
europepmc +1 more source
Immunofluorescence of transfected HEK293 cells.
, 2015 Double-immunofluorescence of contactin-1-, neurofascin-155- and neurofascin-186-transfected HEK293 cells with a control anti-contactin antibody (A, J), control anti-neurofascin155 (D), control anti-neurofascin186 (G) and sera of patients with MMN (B, E ...
Heidrun H. Krämer (776339) +10 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen +22 more
wiley +1 more source
HSCARG regulates ROS generation in HEK293 cells.
, 2013 (A) HEK293 cells were transfected with 2 µg empty vector pRK-FLAG or 2 µg pRK-FLAG -HSCARG for 48 h, and then stimulated with 50 nM PMA for 30 minutes before harvested. Intracellular ROS production was measured by flow cytometry in cells labeled with DCF-
Xiaofeng Zheng (36701) +5 more
core +1 more source
Cavity Microelectrode Arrays for Electrical Recordings From Neurons
Advanced Electronic Materials, EarlyView.Microelectrode arrays (MEAs) are used to study electrophysiological activity. However, their signals are small with high noise. By adding a 100‐nanometer‐high cavity above the electrode, which reduces impedance without affecting resolution, we improve signal quality.
Johannes Lewen +2 more
wiley +1 more source
Subcellular localization of adapter protein Ruk, in HEK293 cells
, 2002 Subcellular localization of adapter protein Ruk1 has been investigated in human embryonic kidney HEK293 cells transfected with pRc/CMV2/Ruk1-Glu-tag. Using immunofluorescence microscopy, it was shown that the recombinant protein was distributed diffusely
Ihumenceva, N. I. +7 more
core +1 more source