Results 161 to 170 of about 4,870,076 (306)
Regulation of ER-Resident Transcription Factor NFE2L1 in HEK293 Cells
Biological and Pharmaceutical BulletinNuclear factor erythroid-derived 2 like 1 (NFE2L1) is reported to be embedded in the endoplasmic reticulum (ER) membrane and subsequently undergo N-glycosylation at several asparagine residues as well as other ER-resident factors including cAMP response element binding protein 3 (CREB3)/ATF6 family members. In this study, we investigated the regulation
Yasui, Maiko +6 more
openaire +2 more sources
siRNA-mediated knock-down of LRP/LR in HEK293 and MDA_MB231 cells.
, 2015 The expression level in HEK293 and MDA_MB231 cells was investigated 72h post-transfection with siRNA-LAMR1. Densitometric analysis of western blot signals revealed a significant (*** p < 0.001) 90.48% and 92.59% reduction in LRP protein expression in A ...
Boitelo T. Letsolo (823248) +10 more
core +1 more source
Advanced Science, EarlyView.This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu +13 more
wiley +1 more source
Modulation of cAMP levels and ERK1/2 phosphorylation in FlpIn-TREx-HEK293-mGPRC6A cells.
, 2016 (A) OCN variants do not stimulate cAMP accumulation in FlpIn-TREx-HEK293 cells stably expressing mGPRC6A (open circles). Neither L-ornithine nor OCN variants inhibit forksolin (3 μM)-stimulated cAMP accumulation in the same cell line (filled circles; OCN
Patricia Rueda (35738) +16 more
core +1 more source
Maternal Hyperglycemia Disrupts Cerebral Cortex Development Through the Foxp1‐Dll1‐Notch Axis
Advanced Science, EarlyView.Maternal hyperglycemia disrupts offspring cortical development through a Foxp1–Dll1–Notch signaling axis. In a PGDM mouse model, intrauterine hyperglycemia decreases cortical thickness and perturbs neuronal layering by downregulating Foxp1, which transcriptionally regulates the Notch ligand Dll1.
Longkai He +12 more
wiley +1 more source
, 2016 Left panel. HEK293 cells stably transfected with NKCC2 were stained for NKCC2 and analyzed with confocal laser-scanning microscopy. Note the proper localization of NKCC2 in this cell line. Bar = 10 μm. Middle panel.
Serena Milano (2805337) +8 more
core +1 more source
Advanced Science, EarlyView.This study identifies ZMIZ2 as a therapeutic target for docetaxel‐resistant triple‐negative breast cancer, sustaining cancer stemness‐associated properties and docetaxel resistance. ZMIZ2 upregulation enhances DUX4‐mediated LGR5 activation through the SWI/SNF components BRG1 and BAF57.
Xueting Gan +9 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Diabetic wounds are characterized by persistent inflammation and impaired immune resolution, yet the therapeutic translation of single‐cell atlases into rational immunomodulatory strategies remains limited. Here, integration of diabetic‐wound single‐cell transcriptomic datasets identifies a neutrophil subpopulation enriched in cluster of ...
Tairong Cui +12 more
wiley +1 more source
Angewandte Chemie, EarlyView.ROXendin668 is a peptidic GLP‐1 receptor agonist that generates toxic singlet oxygen upon irradiation with far‐red light. Pancreatic beta cells can be photo‐ablated in a spatiotemporally controlled manner. This approach has the potential to provide a safer alternative to streptozotocin or alloxan for creating model systems for type 1 diabetes research.
Kilian Roßmann +17 more
wiley +2 more sources
The opioid tramadol blocks the cardiac sodium channel Nav1.5 in HEK293 cells. [PDF]
Europace, 2023 Jia L, Veldkamp MW, Verkerk AO, Tan HL.
europepmc +1 more source