Results 131 to 140 of about 150,776 (304)

Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits

Advanced Science, EarlyView.
Yeast microbes in fermenting fruits attract both host flies and their parasitoid wasps. Female Leptopilina boulardi detect yeast‐emitted ethyl esters via two olfactory receptors, LbouOR167 and LbouOR136. A conserved residue, Leu159, is critical for binding these compounds, enabling female wasps to locate host‐rich habitats.
Yueqi Lu, Lan Pang, Wenqi Shi, Ting Feng, Zhi Dong, Yifeng Sheng, Sicong Zhou, Longtao Yu, Hao Guo, Ying Wang, Jiani Chen, Jianhua Huang   +11 more
wiley   +1 more source

RCAN1 binds HDAC3 in HEK293 cells.

, 2014
(A) Where indicated, HEK293 cells were mock-transfected or transfected with plasmids encoding HA-tagged RCAN1 and/or Flag-tagged HDAC3 for 24 hr. Cell lysates were immunoprecipitated using anti-HA and anti-Flag antibodies, and immunocomplexes were ...
Hye Seon Kang (619345), Eunju Im (122867), Yun Ju Lee (619349), Kyung Ah Han (619344), Lang Yoo (619347), Kwang Chul Chung (122870), Woo Hyun Shin (619350), Jee Won Lee (619346), Ahyoung Hong (619348)   +8 more
core   +1 more source

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

The Effect of Aspirin and Ibuprofen on the Proliferation of Cervical Cancer Cells (HeLa) Compared to Non-Cancerous Cells (HEK 293) in Cell Culture Medium

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2018
Background and Objectives: Studies have shown that anti-inflammatory drugs can affect growth and development of cancer. This study was carried out to determine the effects of aspirin and ibuprofen on viability of cervical cancer cells (HeLa) compared to ...
Rahim Ahmadi, Zahra Karimi Ghezeli, Foroozan Gravand, Mahin Naghshineh   +3 more
doaj  

Engineered AAV2.7m8 Serotype Shows Significantly Higher Transduction Efficiency of ARPE-19 and HEK293 Cell Lines Compared to AAV5, AAV8 and AAV9 Serotypes

Pharmaceutics
The level of transduction efficiency of the target retinal cells affects the choice of AAV serotype and the outcome of gene replacement therapy for inherited retinal diseases.
Dzerassa Gurtsieva, Ekaterina Minskaia, Sofia Zhuravleva, Elena Subcheva, Elena Sakhibgaraeva, Andrew Brovin, Artem Tumaev, Alexander Karabelsky   +7 more
doaj   +1 more source

Comparison of luminescence emission from HEK293-pmeLUC and HEK293-cytLUC cells injected into MZ2-MEL melanoma and healthy tissue.

, 2013
Nude mice were inoculated with MZ2-MEL cells in the right dorsal hip. After about 20 days, when the tumour was about 1–1.5×1–1.5 cm size, HEK293-pmeLUC (A) or HEK293-cytLUC (B) cells were injected s.c.
Lizzia Raffaghello (124257), Francesco Di Virgilio (163523), Patrizia Pellegatti (377262), Vito Pistoia (8759), Federica Piccardi (177418), Giovanna Bianchi (124240)   +5 more
core   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Optimizing In Vitro Efficacy Assessment of the Antisense Oligonucleotide Nusinersen in Human Cellular Models

Pharmaceutics
Background/Objectives: Spinal muscular atrophy (SMA) is a rare genetic disorder caused by mutations or deletions in SMN1, resulting in the loss of SMN protein and severe neuromuscular consequences.
Maša Sinreih Tisnikar, Alja Zottel, Katja Kristan, Tea Lanišnik Rižner   +3 more
doaj   +1 more source

Optimizing size-based sorting of HEK293 cells.

, 2013
(A) The low and high 10% ends of the depicted light-scatter distributions of proliferating HEK293 cells were gated for sorting by FACSAria III. (B) Volume distributions of the sorted low- and high-end cell populations, as determined by Multisizer IV ...
Amit Tzur (232613), Itay Lazar (504205), Manuela Vecsler (349971)   +2 more
core   +1 more source

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

Advanced Science, EarlyView.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang, Tao‐Tao Tang, Wei‐Jie Ni, Jin‐Xuan Wei, Liang‐Yun‐Zi Jiang, Qing Yin, Yi‐Lin Zhang, Zuo‐Lin Li, Yi Wen, Xin‐Lu Wang, Jun‐Yuan Shen, Xiao‐Jun Ouyang, Ming‐Zhu Zheng, Jian Xu, Xiaofei An, Lin‐Li Lv, Bi‐Cheng Liu, Bin Wang   +17 more
wiley   +1 more source