Results 111 to 120 of about 4,870,076 (306)
Advanced Science, EarlyView.Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters +12 more
wiley +1 more source
Measurement of cellular impedance in FlpIn-TREx-HEK293-mGPRC6A cells.
, 2016 (A) ATP (acting via endogenous P2Y receptors) increases cellular impedance in both tetracycline-induced and un-induced FlpIn-TREx-HEK293-mGPRC6A cells, whereas (B) L-ornithine increases cellular impedance only in tetracycline-induced cells.
Patricia Rueda (35738) +16 more
core +1 more source
Advanced Science, EarlyView.Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu +18 more
wiley +1 more source
In Vitro CXCL1 induction in TLR2- and TLR4-transfected HEK293 cells.
, 2013 HEK293 cells stably transfected with human TLR2 (HEK/TLR2) and human TLR4 (HEK/TLR4) as well as untransfected HEK293 cells (HEK -) were incubated with sera from patients with alcoholic cirrhosis (box plots on the right side) and sera from healthy ...
Tilman Sauerbruch (312184) +19 more
core +1 more source
A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau
Advanced Science, EarlyView.TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun +12 more
wiley +1 more source
Optimizing size-based sorting of HEK293 cells.
, 2013 (A) The low and high 10% ends of the depicted light-scatter distributions of proliferating HEK293 cells were gated for sorting by FACSAria III. (B) Volume distributions of the sorted low- and high-end cell populations, as determined by Multisizer IV ...
Amit Tzur (232613) +2 more
core +1 more source
Advanced Science, EarlyView.Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo +10 more
wiley +1 more source
HEK293 cells but not mouse L cells cleave htt to produce a cp-A/1 like fragment.
, 2012 HEK293 and mouse L cells [thymidine kinase negative (TK−)] were transiently transfected with httN171-18Q constructs. After 48 hours, the cells were harvested and analyzed by immunoblot with the htt antibody 2B4.
Andrew T. N. Tebbenkamp (112817) +5 more
core +1 more source
Advanced Science, EarlyView.Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li +17 more
wiley +1 more source
L35Ae interaction with HEK293 cells
, 2015 HEK293 cells were incubated with 6xHis-tagged L35Ae or anti-hCCR7 Fab17 used as a negative control, followed by immunostaining and flow cytometry analysis. FACS buffer contained PBS, 150 mM NaCl, pH 7.0, 1-1.5% calf serum, and 0.01% NaN3. R-Phycoerythrin
Sergei Permyakov (761167) +1 more
core +1 more source