Results 91 to 100 of about 150,776 (304)
, 2018 A-C) Native HEK293 cells and HEK293 cells expressing EGFP-hAQP9 or YFP-hDAT were grown in 96-well plates and exposed to different concentrations of arsenite (eight wells for each concentration).
Torill Berg (4994480) +12 more
core +1 more source
ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells
Advanced Science, EarlyView.With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao +16 more
wiley +1 more source
Huntington’s disease modeling on HEK293 cell line
Vavilov Journal of Genetics and Breeding, 2017 Huntington’s disease is a hereditary neurodegenerative disorder caused by CAG trinucleotide repeat expansion in the first exon of HTT gene. The mutant HTT protein has an elongated polyglutamine tract and forms aggregates in the nuclei and cytoplasm of the striatal neurons. The pathological processes occurring in the medium spiny neurons of Huntington’s
D. V. Sharipova +2 more
openaire +2 more sources
Observed patterns of AdEGFPuci infection in HEK293-mCherry cells.
, 2012 (A) HEK293-mCherry cells were infected at an MOI≪1 and tracked every 24 h beginning at 5 days post-infection when initial spread of infection had occurred.
Dominik Wodarz (34889) +5 more
core +1 more source
Advanced Science, EarlyView.By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao +11 more
wiley +1 more source
The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines.
, 2000 The pharmacology of hSK1, a small conductance calcium-activated potassium channel, was studied in mammalian cell lines (HEK293 and COS-7). In these cell types, hSK1 forms an apamin-sensitive channel with an IC(50) for apamin of 8 nM in HEK293 cells and ...
Shah, M, Haylett, DG
core
Advanced Science, EarlyView.We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel +16 more
wiley +1 more source
Measurement of cellular impedance in FlpIn-TREx-HEK293-mGPRC6A cells.
, 2016 (A) ATP (acting via endogenous P2Y receptors) increases cellular impedance in both tetracycline-induced and un-induced FlpIn-TREx-HEK293-mGPRC6A cells, whereas (B) L-ornithine increases cellular impedance only in tetracycline-induced cells.
Patricia Rueda (35738) +16 more
core +1 more source
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Analysis of bFos-bJun interactions in HEK293 cells.
, 2013 (A) HAVI-Fluc-bJun associated with Rluc-bFos when co-expressed in HEK293 cells using the DLR-PD assay. HEK293 cells were co-transfected with the indicated expression vectors (100 ng), and the DLR-PD assay was performed.
Shuaizheng Jia (341570) +7 more
core +1 more source