Results 81 to 90 of about 194,330 (301)

Methyl-Cantharidimide (MCA) Has Anticancer Efficacy in ABCB1- and ABCG2-Overexpressing and Cisplatin Resistant Cancer Cells

Frontiers in Oncology, 2020
In this study, we investigated the efficacy of methyl-cantharidimide (MCA), a cantharidin (CTD) analog, as an anticancer drug, in cancer cells overexpressing either ABCB1 or ABCG2 transporters and in cisplatin-resistant cancer cells.
Yi-Dong Li, Yong Mao, Xing-Duo Dong, Zi-Ning Lei, Yuqi Yang, Lizhu Lin, Charles R. Ashby, Dong-Hua Yang, Ying-Fang Fan, Ying-Fang Fan, Zhe-Sheng Chen   +10 more
doaj   +1 more source

Overexpression of G-protein-coupled receptor 40 enhances the mitogenic response to epoxyeicosatrienoic acids. [PDF]

PLoS ONE, 2015
The cytochrome P450 epoxygenase-dependent arachidonic acid metabolites, epoxyeicosatrienoic acids (EETs), are potent survival factors and mitogens for renal epithelial cells, but the molecular identity in the cells that initiates the mitogenic signaling ...
Seong Kwon Ma, Yinqiu Wang, Jianchun Chen, Ming-Zhi Zhang, Raymond C Harris, Jian-Kang Chen   +5 more
doaj   +1 more source

A novel FRET-based screen in high-throughput format to identify inhibitors of malarial and human glucose transporters [PDF]

, 2016
The glucose transporter PfHT is essential to the survival of the malaria parasite Plasmodium falciparum and has been shown to be a druggable target with high potential for pharmacological intervention.
Autry, Joseph M, Edwards, Rachel L, Heitmeier, Monique R, Hruz, Paul W, Ilagan, Ma Xenia G, Kraft, Thomas E, Odom, Audrey R, Payne, Maria A, Putanko, Marina, Thomas, David D   +9 more
core   +2 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Nicotinic acetylcholine receptor (CHRN) expression and function in cultured human adult fungiform (HBO) taste cells. [PDF]

PLoS ONE, 2018
In rodents, CHRNs are involved in bitter taste transduction of nicotine and ethanol. Currently, it is not clear if CHRNs are expressed in human taste cells and if they play a role in transducing the bitter taste of nicotine and ethanol or in the ...
Jie Qian, Shobha Mummalaneni, James Larsen, John R Grider, Andrew I Spielman, Mehmet Hakan Özdener, Vijay Lyall   +6 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Knocking out Ornithine Decarboxylase Antizyme 1 (OAZ1) Improves Recombinant Protein Expression in the HEK293 Cell Line

Medical Sciences, 2018
Creating efficient cell lines is a priority for the biopharmaceutical industry, which produces biologicals for various uses. A recent approach to achieving this goal is the use of non-coding RNAs, microRNA (miRNA) and small interfering RNA (siRNA), to ...
Laura Abaandou, Joseph Shiloach
doaj   +1 more source

TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel [PDF]

, 2014
Transient receptor potential (TRP) channels, a superfamily of ion channels, can be divided into 7 subfamilies, including TRPV, TRPC, TRPP, and 4 others. Functional TRP channels are tetrameric complexes consisting of 4 pore-forming subunits.
Birnbaumer, Lutz, Du, Juan, Huang, Yu, Ma, Xin, Shen, Bing, Yao, Xiaoqiang   +5 more
core   +1 more source

Deciphering µ‐opioid receptor phosphorylation and dephosphorylation in HEK293 cells [PDF]

British Journal of Pharmacology, 2012
BACKGROUND AND PURPOSEThe molecular basis of agonist‐selective signalling at the µ‐opioid receptor is poorly understood. We have recently shown that full agonists such as [D‐Ala2‐MePhe4‐Gly‐ol]enkephalin (DAMGO) stimulate the phosphorylation of a number of carboxyl‐terminal phosphate acceptor sites including threonine 370 (Thr370) and serine 375 ...
Christian, Doll, Florian, Pöll, Kenneth, Peuker, Anastasia, Loktev, Laura, Glück, Stefan, Schulz   +5 more
openaire   +2 more sources

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source