Results 61 to 70 of about 4,870,076 (306)
, 2013 (A) Western blot analysis of TLR-2 and TLR-5 proteins in HEK293, HEK293-TLR2 and HEK293-TLR5 cell lines. (B) Fold changes of mRNA expression of TLR-2 and TLR-5 in HEK293, HEK293-TLR2 and HEK293-TLR5 cell lines infected with H.
Sabine Brandt (123497) +3 more
core +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Orai1 Expression, Mitosis and Cell Cycle Progression in HEK293 Cells [PDF]
Biophysical Journal, 2010 Calcium influx is needed for cell proliferation and recent identification of Orai1 as the main constituent for both store-operated (SOCE) and non capacitative (NCCE) calcium entries led us to investigate the role of Orai1 in mitosis and cell cycle progression in HEK293 cells.
Borowiec, Anne-Sophie +8 more
openaire +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Nanomaterials, 2019 Graphene, a two-dimensional carbon sheet with single-atom thickness, shows immense promise in several nanoscientific and nanotechnological applications, including in sensors, catalysis, and biomedicine.
Sangiliyandi Gurunathan +12 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
, 2014 1, proteins isolated from HEK293 cells with gfp under control of the CMV promoter; 2–4, proteins isolated from HEK293/B7 cells; 5–6, proteins isolated from HEK293/F7 cells; 7, proteins isolated from HEK293 cells.
Ekaterina Savchenko (610852) +5 more
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells [PDF]
Molecular Therapy - Methods & Clinical Development, 2019 Adeno-associated virus (AAV) vectors are currently among the most commonly applied for in vivo gene therapy approaches. The evaluation of vectors during clinical development requires the production of considerable amounts of highly pure and potent vectors.
Blessing, Daniel +7 more
openaire +5 more sources
IC50 for 6-MP on HEK293 and HEK293/MRP4 cells independently or in the presence of MRP4 inhibitors.
, 2018 IC50 for 6-MP on HEK293 and HEK293/MRP4 cells independently or in the presence of MRP4 inhibitors.
Zhenming Liu (448850) +5 more
core +1 more source